Droplet-based microextraction in the aqueous two-phase system

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This report is about microfluidic extraction systems based on droplets of aqueous two-phase system. Mass transfer between continuous phase and dispersed droplet is demonstrated by microextraction of ruthenium red in a microfluidic device. Droplets are generated with electrohydrodynamic method in the same device. By comparing brightness in the digital image of a solution with known concentrations of ruthenium red and those of a droplet in the microextraction, ruthenium red concentration was measured along the microextraction channel, resulting in good agreement with a simple diffusion model. The maximum partition coefficient was 9.58 in the experiment with the 70-mm-long-channel microextractor. The method is usable for terminating microextraction by electrohydrodynamic manipulation of droplet movement direction. Droplets of different ruthenium red concentration, 0.12 and 0.24% (w/w) in this experiment, can be moved to desired place of microfluidic system for further reaction through respectively branched outlets. In this study droplet-based microextraction is demonstrated and the mass transport is numerically analyzed by solving the diffusion-dissolution model. (C) 2010 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2010-06
Language
English
Article Type
Article
Keywords

LIQUID-LIQUID-EXTRACTION; MICROFLUIDIC DEVICE; ELECTROHYDRODYNAMIC GENERATION; SOLVENT-EXTRACTION; FLOW; MICROCHANNELS; DIFFUSION; PROTEINS; CHIP

Citation

JOURNAL OF CHROMATOGRAPHY A, v.1217, no.24, pp.3723 - 3728

ISSN
0021-9673
DOI
10.1016/j.chroma.2010.04.015
URI
http://hdl.handle.net/10203/22025
Appears in Collection
CBE-Journal Papers(저널논문)
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