Dissecting Selectivity of Neuromodulatory Projections to Sensory Cortices

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 327
  • Download : 0
Neuromodulatory inputs from the basal forebrain (BF) and locus ceruleus (LC) are widespread in the mammalian cerebral cortex and are known to play important roles in attention and arousal, but little is known about the selectivity of their cortical projections. Using a dual retrobead tracing technique along with optogenetic stimulation, we have identified anatomic and functional differences in the way cholinergic BF neurons and noradrenergic LC neurons project into primary sensory cortices. While BF projections are highly selective to individual sensory cortices, LC projections diverge into multiple sensory cortices. To our knowledge, this is the first definitive proof that BF and LC projections to primary sensory cortices show both anatomic and functional differences in selectivity for modulating cortical activity.
Publisher
KSMCB
Issue Date
2016-10-14
Language
English
Citation

2016 International Conference of the Korean Society for Molecular and Cellular Biology

URI
http://hdl.handle.net/10203/219934
Appears in Collection
BS-Conference Papers(학술회의논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0