DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sharker, Shazid Md. | ko |
dc.contributor.author | Kang, Eun Bi | ko |
dc.contributor.author | Shin, Chun-Im | ko |
dc.contributor.author | Kim, Sung Han | ko |
dc.contributor.author | Lee, Gibaek | ko |
dc.contributor.author | Park, Sung Young | ko |
dc.date.accessioned | 2016-09-06T07:15:15Z | - |
dc.date.available | 2016-09-06T07:15:15Z | - |
dc.date.created | 2016-07-26 | - |
dc.date.created | 2016-07-26 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | JOURNAL OF APPLIED POLYMER SCIENCE, v.133, no.32 | - |
dc.identifier.issn | 0021-8995 | - |
dc.identifier.uri | http://hdl.handle.net/10203/212241 | - |
dc.description.abstract | Hybrid nanoparticles for theragnosis have great potentiality to bring desire functionalities in one integrated system. The development of bioimaging guided photothermal therapy (PTT) is pivotal in optimizing cytotoxic cancer therapy. We report nearinfrared (NIR)-active and pH-responsive fluorescent, catechol-conjugated, reduced graphene oxide (rGO)-anchored hybrid nanoparticles that can sharply increase the photothermal heat in response to NIR exposure and exhibit pH-dependent fluorescence emission for the detection of tumor areas without causing cell toxicity. The optoelectronic absorption property of poly(3,4-ethylenedioxythiophene) [PEDOT]: dopamine-conjugated poly(4-styrenesulfonate-co-maleic acid) [D-PSM] and 3',4'-dihydroxyacetophenone/boron-dipyrromethene [CCDP/BODIPY]-quaternized polyethylene glycol grafted poly(dimethylaminoethyl methacrylate) (C/B-PgP) present in this hybrid nanoparticles resulted in efficient photothermal conversion with pH-tunable fluorescence that exerted sufficient photothermal cytotoxicity to cancer cells. The in vitro cellular uptake was measured by confocal laser scanning microscopy, allowing the therapeutic efficiency and bioimaging effects to be explored. We expect that the broad optical absorption property of PEDOT:D-PSM with BODIPY-conjugated polymers on rGO sheets would get tremendous attraction in this enormous rising PTT with cancer detectable biomarker. (C) 2016 Wiley Periodicals, Inc | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | VIVO PHOTOTHERMAL THERAPY | - |
dc.subject | BODIPY-CONJUGATED POLYMER | - |
dc.subject | IN-VITRO | - |
dc.subject | ORGANIC NANOPARTICLES | - |
dc.subject | CARBON NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CONDUCTIVITY | - |
dc.subject | PERFORMANCE | - |
dc.subject | PEDOT | - |
dc.subject | NANOMATERIALS | - |
dc.title | Near-infrared-active and pH-responsive fluorescent polymer-integrated hybrid graphene oxide nanoparticles for the detection and treatment of cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000378429900024 | - |
dc.identifier.scopusid | 2-s2.0-84966356405 | - |
dc.type.rims | ART | - |
dc.citation.volume | 133 | - |
dc.citation.issue | 32 | - |
dc.citation.publicationname | JOURNAL OF APPLIED POLYMER SCIENCE | - |
dc.identifier.doi | 10.1002/app.43791 | - |
dc.contributor.nonIdAuthor | Kang, Eun Bi | - |
dc.contributor.nonIdAuthor | Shin, Chun-Im | - |
dc.contributor.nonIdAuthor | Kim, Sung Han | - |
dc.contributor.nonIdAuthor | Lee, Gibaek | - |
dc.contributor.nonIdAuthor | Park, Sung Young | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | applications | - |
dc.subject.keywordAuthor | biocompatibility | - |
dc.subject.keywordAuthor | biomaterials | - |
dc.subject.keywordAuthor | drug delivery systems | - |
dc.subject.keywordAuthor | stimulisensitive polymers | - |
dc.subject.keywordPlus | VIVO PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | BODIPY-CONJUGATED POLYMER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ORGANIC NANOPARTICLES | - |
dc.subject.keywordPlus | CARBON NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CONDUCTIVITY | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | PEDOT | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.