Acid sensing by the Drosophila olfactory system

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The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating(1). How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors(2). In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery
Publisher
NATURE PUBLISHING GROUP
Issue Date
2010-12
Language
English
Article Type
Article
Keywords

CARBON-DIOXIDE; CHEMOSENSORY RECEPTORS; TARGETED EXPRESSION; AVOIDANCE-BEHAVIOR; FLY BRAIN; NEURONS; TRANSMISSION; MELANOGASTER; REVEALS; MINOS

Citation

NATURE, v.468, no.7324, pp.691 - U112

ISSN
0028-0836
DOI
10.1038/nature09537
URI
http://hdl.handle.net/10203/211911
Appears in Collection
BS-Journal Papers(저널논문)
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