DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ai, Minrong | ko |
dc.contributor.author | Min, Soohong | ko |
dc.contributor.author | Grosjean, Yael | ko |
dc.contributor.author | Leblanc, Charlotte | ko |
dc.contributor.author | Bell, Rati | ko |
dc.contributor.author | Benton, Richard | ko |
dc.contributor.author | Suh, Greg S. B. | ko |
dc.date.accessioned | 2016-07-25T08:30:50Z | - |
dc.date.available | 2016-07-25T08:30:50Z | - |
dc.date.created | 2016-07-12 | - |
dc.date.created | 2016-07-12 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | NATURE, v.468, no.7324, pp.691 - U112 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/211911 | - |
dc.description.abstract | The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating(1). How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors(2). In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CARBON-DIOXIDE | - |
dc.subject | CHEMOSENSORY RECEPTORS | - |
dc.subject | TARGETED EXPRESSION | - |
dc.subject | AVOIDANCE-BEHAVIOR | - |
dc.subject | FLY BRAIN | - |
dc.subject | NEURONS | - |
dc.subject | TRANSMISSION | - |
dc.subject | MELANOGASTER | - |
dc.subject | REVEALS | - |
dc.subject | MINOS | - |
dc.title | Acid sensing by the Drosophila olfactory system | - |
dc.type | Article | - |
dc.identifier.wosid | 000284836700040 | - |
dc.identifier.scopusid | 2-s2.0-78649874500 | - |
dc.type.rims | ART | - |
dc.citation.volume | 468 | - |
dc.citation.issue | 7324 | - |
dc.citation.beginningpage | 691 | - |
dc.citation.endingpage | U112 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature09537 | - |
dc.contributor.localauthor | Suh, Greg S. B. | - |
dc.contributor.nonIdAuthor | Ai, Minrong | - |
dc.contributor.nonIdAuthor | Min, Soohong | - |
dc.contributor.nonIdAuthor | Grosjean, Yael | - |
dc.contributor.nonIdAuthor | Leblanc, Charlotte | - |
dc.contributor.nonIdAuthor | Bell, Rati | - |
dc.contributor.nonIdAuthor | Benton, Richard | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CARBON-DIOXIDE | - |
dc.subject.keywordPlus | CHEMOSENSORY RECEPTORS | - |
dc.subject.keywordPlus | TARGETED EXPRESSION | - |
dc.subject.keywordPlus | AVOIDANCE-BEHAVIOR | - |
dc.subject.keywordPlus | FLY BRAIN | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | MINOS | - |
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