beta-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development

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beta-Arrestins have been implicated in the regulation of multiple signalling pathways. However, their role in organism development is not well understood. In this study, we report a new in vivo function of the Drosophila beta-arrestin Kurtz (Krz) in the regulation of two distinct developmental signalling modules: MAPK ERK and NF-kappa B, which transmit signals from the activated receptor tyrosine kinases (RTKs) and the Toll receptor, respectively. Analysis of the expression of effectors and target genes of Toll and the RTK Torso in krz maternal mutants reveals that Krz limits the activity of both pathways in the early embryo. Protein interaction studies suggest a previously uncharacterized mechanism for ERK inhibition: Krz can directly bind and sequester an inactive form of ERK, thus preventing its activation by the upstream kinase, MEK. A simultaneous dysregulation of different signalling systems in krz mutants results in an abnormal patterning of the embryo and severe developmental defects. Our findings uncover a new in vivo function of beta-arrestins and present a new mechanism of ERK inhibition by the Drosophila beta-arrestin Krz.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2010-10
Language
English
Article Type
Article
Keywords

RECEPTOR TYROSINE KINASE; NONVISUAL ARRESTIN; PATTERN-FORMATION; DORSAL MORPHOGEN; ACTIVATION; PATHWAYS; PROTEIN; GENE; BETA-ARRESTIN-2; REPRESSION

Citation

EMBO JOURNAL, v.29, no.19, pp.3222 - 3235

ISSN
0261-4189
DOI
10.1038/emboj.2010.202
URI
http://hdl.handle.net/10203/211828
Appears in Collection
CBE-Journal Papers(저널논문)
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