A Chemically Induced Vaccine Strategy for Prostate Cancer

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Here we report the design and evaluation of a bifunctional, small molecule switch that induces a targeted immune response against tumors in vivo. A high affinity ligand for prostate specific membrane,antigen (PSMA) was conjugated to a hapten that binds dinitrophenyl (DNP)-specific antibodies.,When introduced into hu-PBL-NOD/SCID mice previously immunized with a KLH-DNP immunogen, this conjugate induced a targeted antibody-dependent cellular cytotoxicity (AD CC) response to PSMA-expressing tumor cells in a mouse xenograft Model. The ability to-create a small molecule inducible antibody response against self antigens using endogenous non-autoreactive antibodies may provide advantages over the autologous immune response generated by conventional vaccines in certain therapeutic settings.
Publisher
AMER CHEMICAL SOC
Issue Date
2011-11
Language
English
Article Type
Article
Keywords

COMBINED IMMUNODEFICIENT MICE; PERIPHERAL-BLOOD LYMPHOCYTES; IMMUNE-RESPONSE; SCID MICE; RECEPTORS; TUMOR; IMMUNOTHERAPY; THERAPY; SYSTEM; LIGAND

Citation

ACS CHEMICAL BIOLOGY, v.6, no.11, pp.1223 - 1231

ISSN
1554-8929
DOI
10.1021/cb200222s
URI
http://hdl.handle.net/10203/209143
Appears in Collection
BS-Journal Papers(저널논문)
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