DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dubrovska, Anna | ko |
dc.contributor.author | Kim, Chan Hyuk | ko |
dc.contributor.author | Elliott, Jimmy | ko |
dc.contributor.author | Shen, Weijun | ko |
dc.contributor.author | Kuo, Tun-Hsun | ko |
dc.contributor.author | Koo, Dong-In | ko |
dc.contributor.author | Li, Chun | ko |
dc.contributor.author | Tuntland, Tove | ko |
dc.contributor.author | Chang, Jonathan | ko |
dc.contributor.author | Groessl, Todd | ko |
dc.contributor.author | Wu, Xu | ko |
dc.contributor.author | Gorney, Vanessa | ko |
dc.contributor.author | Ramirez-Montagut, Teresa | ko |
dc.contributor.author | Spiegel, David A. | ko |
dc.contributor.author | Cho, Charles Y. | ko |
dc.contributor.author | Schultz, Peter G. | ko |
dc.date.accessioned | 2016-07-04T06:03:40Z | - |
dc.date.available | 2016-07-04T06:03:40Z | - |
dc.date.created | 2016-05-13 | - |
dc.date.created | 2016-05-13 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | ACS CHEMICAL BIOLOGY, v.6, no.11, pp.1223 - 1231 | - |
dc.identifier.issn | 1554-8929 | - |
dc.identifier.uri | http://hdl.handle.net/10203/209143 | - |
dc.description.abstract | Here we report the design and evaluation of a bifunctional, small molecule switch that induces a targeted immune response against tumors in vivo. A high affinity ligand for prostate specific membrane,antigen (PSMA) was conjugated to a hapten that binds dinitrophenyl (DNP)-specific antibodies.,When introduced into hu-PBL-NOD/SCID mice previously immunized with a KLH-DNP immunogen, this conjugate induced a targeted antibody-dependent cellular cytotoxicity (AD CC) response to PSMA-expressing tumor cells in a mouse xenograft Model. The ability to-create a small molecule inducible antibody response against self antigens using endogenous non-autoreactive antibodies may provide advantages over the autologous immune response generated by conventional vaccines in certain therapeutic settings. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | COMBINED IMMUNODEFICIENT MICE | - |
dc.subject | PERIPHERAL-BLOOD LYMPHOCYTES | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.subject | SCID MICE | - |
dc.subject | RECEPTORS | - |
dc.subject | TUMOR | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | THERAPY | - |
dc.subject | SYSTEM | - |
dc.subject | LIGAND | - |
dc.title | A Chemically Induced Vaccine Strategy for Prostate Cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000297038800011 | - |
dc.identifier.scopusid | 2-s2.0-81555214659 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 1223 | - |
dc.citation.endingpage | 1231 | - |
dc.citation.publicationname | ACS CHEMICAL BIOLOGY | - |
dc.identifier.doi | 10.1021/cb200222s | - |
dc.contributor.localauthor | Kim, Chan Hyuk | - |
dc.contributor.nonIdAuthor | Dubrovska, Anna | - |
dc.contributor.nonIdAuthor | Elliott, Jimmy | - |
dc.contributor.nonIdAuthor | Shen, Weijun | - |
dc.contributor.nonIdAuthor | Kuo, Tun-Hsun | - |
dc.contributor.nonIdAuthor | Koo, Dong-In | - |
dc.contributor.nonIdAuthor | Li, Chun | - |
dc.contributor.nonIdAuthor | Tuntland, Tove | - |
dc.contributor.nonIdAuthor | Chang, Jonathan | - |
dc.contributor.nonIdAuthor | Groessl, Todd | - |
dc.contributor.nonIdAuthor | Wu, Xu | - |
dc.contributor.nonIdAuthor | Gorney, Vanessa | - |
dc.contributor.nonIdAuthor | Ramirez-Montagut, Teresa | - |
dc.contributor.nonIdAuthor | Spiegel, David A. | - |
dc.contributor.nonIdAuthor | Cho, Charles Y. | - |
dc.contributor.nonIdAuthor | Schultz, Peter G. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COMBINED IMMUNODEFICIENT MICE | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD LYMPHOCYTES | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | SCID MICE | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | LIGAND | - |
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