Nanomedicine for Infectious Disease Applications: Innovation towards Broad-Spectrum Treatment of Viral Infections

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Nanomedicine enables unique diagnostic and therapeutic capabilities to tackle problems in clinical medicine. As multifunctional agents with programmable properties, nanomedicines are poised to revolutionize treatment strategies. This promise is especially evident for infectious disease applications, for which the continual emergence, re-emergence, and evolution of pathogens has proven difficult to counter by conventional approaches. Herein, a conceptual framework is presented that envisions possible routes for the development of nanomedicines as superior broad-spectrum antiviral agents against enveloped viruses. With lipid membranes playing a critical role in the life cycle of medically important enveloped viruses including HIV, influenza, and Ebola, cellular and viral membrane interfaces are ideal elements to incorporate into broad-spectrum antiviral strategies. Examples are presented that demonstrate how nanomedicine strategies inspired by lipid membranes enable a wide range of targeting opportunities to gain control of critical stages in the virus life cycle through either direct or indirect approaches involving membrane interfaces. The capabilities can be realized by enabling new inhibitory functions or improving the function of existing drugs through nanotechnology-enabled solutions. With these exciting opportunities, due attention is also given to the clinical translation of nanomedicines for infectious disease applications, especially as pharmaceutical drug-discovery pipelines demand new routes of innovation
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2016-03
Language
English
Article Type
Article
Keywords

HEPATITIS-C VIRUS; MULTIVALENT GOLD NANOPARTICLES; AMPHIPATHIC FUSION INHIBITOR; ALPHA-HELICAL PEPTIDE; ENVELOPED VIRUSES; SILVER NANOPARTICLES; LIPID-MEMBRANES; INFLUENZA-VIRUS; HIV; DELIVERY

Citation

SMALL, v.12, no.9, pp.1133 - 1139

ISSN
1613-6810
DOI
10.1002/smll.201500854
URI
http://hdl.handle.net/10203/208480
Appears in Collection
MT-Journal Papers(저널논문)
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