DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Carol | ko |
dc.contributor.author | Carter, Andrew P. | ko |
dc.contributor.author | Jin, Lan | ko |
dc.contributor.author | Vale, Ronald D. | ko |
dc.date.accessioned | 2016-05-16T02:39:44Z | - |
dc.date.available | 2016-05-16T02:39:44Z | - |
dc.date.created | 2016-02-24 | - |
dc.date.created | 2016-02-24 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | SCIENCE, v.331, no.6021, pp.1159 - 1165 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207334 | - |
dc.description.abstract | Dyneins are microtubule-based motor proteins that power ciliary beating, transport intracellular cargos, and help to construct the mitotic spindle. Evolved from ring-shaped hexameric AAA-family adenosine triphosphatases (ATPases), dynein's large size and complexity have posed challenges for understanding its structure and mechanism. Here, we present a 6 angstrom crystal structure of a functional dimer of two similar to 300-kilodalton motor domains of yeast cytoplasmic dynein. The structure reveals an unusual asymmetric arrangement of ATPase domains in the ring-shaped motor domain, the manner in which the mechanical element interacts with the ATPase ring, and an unexpected interaction between two coiled coils that create a base for the microtubule binding domain. The arrangement of these elements provides clues as to how adenosine triphosphate-driven conformational changes might be transmitted across the motor domain. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.subject | MICROTUBULE-BINDING DOMAIN | - |
dc.subject | REPLICATIVE HEXAMERIC HELICASE | - |
dc.subject | CYTOPLASMIC DYNEIN | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | CONFORMATIONAL-CHANGE | - |
dc.subject | ENERGY TRANSDUCTION | - |
dc.subject | COILED-COIL | - |
dc.subject | MECHANISMS | - |
dc.subject | PROTEINS | - |
dc.subject | MOTIONS | - |
dc.title | Crystal Structure of the Dynein Motor Domain | - |
dc.type | Article | - |
dc.identifier.wosid | 000287971200033 | - |
dc.type.rims | ART | - |
dc.citation.volume | 331 | - |
dc.citation.issue | 6021 | - |
dc.citation.beginningpage | 1159 | - |
dc.citation.endingpage | 1165 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.1202393 | - |
dc.contributor.nonIdAuthor | Carter, Andrew P. | - |
dc.contributor.nonIdAuthor | Jin, Lan | - |
dc.contributor.nonIdAuthor | Vale, Ronald D. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MICROTUBULE-BINDING DOMAIN | - |
dc.subject.keywordPlus | REPLICATIVE HEXAMERIC HELICASE | - |
dc.subject.keywordPlus | CYTOPLASMIC DYNEIN | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | CONFORMATIONAL-CHANGE | - |
dc.subject.keywordPlus | ENERGY TRANSDUCTION | - |
dc.subject.keywordPlus | COILED-COIL | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | MOTIONS | - |
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