Construction and optimization of synthetic pathways in metabolic engineering

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Metabolic engineering has enabled us to develop strains suitable for their use as microbial factories of chemicals and materials from renewable sources. It has recently become more powerful with the advanced in synthetic biology, which is allowing us to create novel and fine-controlled metabolic and regulatory circuits maximizing metabolic fluxes to the desired products in the strain being developed. This enables us to engineer host microorganisms to enhance their innate metabolic capabilities or to gain new capabilities in the production of target compounds. Here we review recently constructed synthetic pathways that have been successfully applied for producing non-innate chemicals and also discuss recent approaches developed to increase the efficiency of synthetic pathways for achieving higher productivities of desired bioproducts.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2010-06
Language
English
Article Type
Review
Citation

CURRENT OPINION IN MICROBIOLOGY, v.13, no.3, pp.363 - 370

ISSN
1369-5274
DOI
10.1016/j.mib.2010.02.004
URI
http://hdl.handle.net/10203/20209
Appears in Collection
CBE-Journal Papers(저널논문)
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