DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JH | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.date.accessioned | 2010-11-16T04:55:22Z | - |
dc.date.available | 2010-11-16T04:55:22Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | CURRENT OPINION IN BIOTECHNOLOGY, v.19, no.5, pp.454 - 460 | - |
dc.identifier.issn | 0958-1669 | - |
dc.identifier.uri | http://hdl.handle.net/10203/20011 | - |
dc.description.abstract | Microorganisms capable of efficient production of amino acids have traditionally been developed by random mutation and selection method, which might cause unwanted physiological changes in cellular metabolism. Rational genome-wide metabolic engineering based on systems and synthetic biology tools, which is termed 'systems metabolic engineering', is rising as an alternative to overcome these problems. Recently, several amino acid producers have been successfully developed by systems metabolic engineering, where the metabolic engineering procedures were performed within a systems biology framework, and entire metabolic networks, including complex. regulatory circuits, were engineered in an integrated manner. Here we review the current status of systems metabolic engineering successfully applied for developing amino acid producing strains and discuss future prospects. | - |
dc.description.sponsorship | We thank Seung Bum Sohn for his help in manuscript preparation. This work was supported by the Korean Systems Biology Project from the Ministry of Education, Science and Technology through the Korea Science and Engineering Foundation. Further supports by LG Chem Chair Professorship and Microsoft are appreciated. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | CURRENT BIOLOGY LTD | - |
dc.title | Towards systems metabolic engineering of microorganisms for amino acid production | - |
dc.type | Article | - |
dc.identifier.wosid | 000260387900007 | - |
dc.identifier.scopusid | 2-s2.0-53049087092 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 454 | - |
dc.citation.endingpage | 460 | - |
dc.citation.publicationname | CURRENT OPINION IN BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1016/j.copbio.2008.08.007 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.nonIdAuthor | Park, JH | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | L-LYSINE PRODUCTION | - |
dc.subject.keywordPlus | GLOBAL EXPRESSION CHANGES | - |
dc.subject.keywordPlus | L-SERINE PRODUCTION | - |
dc.subject.keywordPlus | CORYNEBACTERIUM-GLUTAMICUM | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | MANNHEIMIA-SUCCINICIPRODUCENS | - |
dc.subject.keywordPlus | L-ISOLEUCINE | - |
dc.subject.keywordPlus | TRANSCRIPTION MACHINERY | - |
dc.subject.keywordPlus | STRAIN IMPROVEMENT | - |
dc.subject.keywordPlus | VALINE PRODUCTION | - |
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