DC Field | Value | Language |
---|---|---|
dc.contributor.author | Babu, Eththilu | ko |
dc.contributor.author | Mareeswaran, Paulpandian Muthu | ko |
dc.contributor.author | Sathish, Veerasamy | ko |
dc.contributor.author | Singaravadivel, Subramanian | ko |
dc.contributor.author | Rajagopal, Seenivasan | ko |
dc.date.accessioned | 2015-04-08T07:54:24Z | - |
dc.date.available | 2015-04-08T07:54:24Z | - |
dc.date.created | 2015-03-30 | - |
dc.date.created | 2015-03-30 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | TALANTA, v.134, pp.348 - 353 | - |
dc.identifier.issn | 0039-9140 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195908 | - |
dc.description.abstract | Aggregation of amyloid-beta (A beta) peptide has been known to be pathologically associated with Alzheimer and dementia diseases. Amyloid-beta fibrils serve as an important target for the drugs development and diagnosis of neurodegenerative diseases. Herein, we report a new [Ru(dmbpy)(dcbpy)dppz)] complex (dmbpy; 4,4'-dimethyl-2,2'-bipyridine, dcbpy; 4,4'-dicorboxy-2,2'-bipyridine, dppz; dipyridophenazine) intercalated aptamer based recognition of amyloid-beta. Interestingly, aforementioned Ru(II) complex shows weak luminescence intensity in the aqueous medium but it shows strong luminescence intensity in the presence of RNA aptamer. Upon addition of amyloid-beta monomers, the luminescence intensity of Ru(II) complex is reduced due to the strong interaction of aptamer with amyloid-beta monomer/small oligomers. Furthermore, present study implies that our system has ability to inhibit the formation of amyloid-beta fibrils, which is confirmed from the AFM morphological structures in the absence and presence of aptamer. This work may contribute the rapid diagnosis and inhibition of amyloid-beta aggregation in the clinical applications. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | BOVINE SERUM-ALBUMIN | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | PROTEIN | - |
dc.subject | AGGREGATION | - |
dc.subject | FIBRIL | - |
dc.subject | PROBE | - |
dc.subject | ASSEMBLIES | - |
dc.subject | DESIGN | - |
dc.subject | MEMORY | - |
dc.subject | SENSOR | - |
dc.title | Sensing and inhibition of amyloid-beta based on the simple luminescent aptamer-ruthenium complex system | - |
dc.type | Article | - |
dc.identifier.wosid | 000349723600046 | - |
dc.identifier.scopusid | 2-s2.0-84918791835 | - |
dc.type.rims | ART | - |
dc.citation.volume | 134 | - |
dc.citation.beginningpage | 348 | - |
dc.citation.endingpage | 353 | - |
dc.citation.publicationname | TALANTA | - |
dc.identifier.doi | 10.1016/j.talanta.2014.11.020 | - |
dc.contributor.localauthor | Mareeswaran, Paulpandian Muthu | - |
dc.contributor.nonIdAuthor | Babu, Eththilu | - |
dc.contributor.nonIdAuthor | Sathish, Veerasamy | - |
dc.contributor.nonIdAuthor | Singaravadivel, Subramanian | - |
dc.contributor.nonIdAuthor | Rajagopal, Seenivasan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Aptamers | - |
dc.subject.keywordAuthor | Amyloid-beta | - |
dc.subject.keywordAuthor | Amyloid-beta fibrils | - |
dc.subject.keywordAuthor | Ruthenium(II) complexes | - |
dc.subject.keywordAuthor | Luminescence | - |
dc.subject.keywordAuthor | Biosensors | - |
dc.subject.keywordPlus | BOVINE SERUM-ALBUMIN | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | FIBRIL | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordPlus | ASSEMBLIES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | SENSOR | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.