As productions and deliveries of multiple products to multiple marketplaces have been increasingly popular, supplychain flexibility, which refers to an ability to deal with demand and capacity uncertainty, becomes an important issuein supply chain management. However, logistics costs have been largely neglected in the literature on supply chainflexibility structure. In this paper, we propose mathematical models to investigate the impact of the logistics costson the optimal flexibility structure. We also conduct a simulation study and observe that logistics costs have a significantimpact on the decision on supply chain flexibility structure. Such conclusion is also supported by the casestudy of a global car manufacturer, Honda Motors.