DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Yu | ko |
dc.contributor.author | Kim, Jin Ho | ko |
dc.contributor.author | Bae, Ki-Hyun | ko |
dc.contributor.author | Oh, Mi Hwa | ko |
dc.contributor.author | Kim, Youngwook | ko |
dc.contributor.author | Kim, Jee-Seon | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.contributor.author | Park, Keunchil | ko |
dc.contributor.author | Lee, Jung Hee | ko |
dc.contributor.author | Nam, Yoon-Sung | ko |
dc.date.accessioned | 2015-04-07T05:03:39Z | - |
dc.date.available | 2015-04-07T05:03:39Z | - |
dc.date.created | 2015-02-24 | - |
dc.date.created | 2015-02-24 | - |
dc.date.created | 2015-02-24 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | SMALL, v.11, no.2, pp.222 - 231 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195266 | - |
dc.description.abstract | This study introduces multifunctional lipid nanoparticles (LNPs), mimicking the structure and compositions of low-density lipoproteins, for the tumor-targeted co-delivery of anti-cancer drugs and superparamagnetic nanocrystals. Paclitaxel (4.7 wt%) and iron oxide nanocrystals (6.8 wt%, 11 nm in diameter) are co-encapsulated within folate-functionalized LNPs, which contain a cluster of nanocrystals with an overall diameter of about 170 nm and a zeta potential of about -40 mV. The folate-functionalized LNPs enable the targeted detection of MCF-7, human breast adenocarcinoma expressing folate receptors, in T-2-weighted magnetic resonance images as well as the efficient intracellular delivery of paclitaxel. Paclitaxel-free LNPs show no significant cytotoxicity up to 0.2 mg mL(-1), indicating the excellent biocompatibility of the LNPs for intracellular drug delivery applications. The targeted anti-tumor activities of the LNPs in a mouse tumor model suggest that the low-density lipoprotein-mimetic LNPs can be an effective theranostic platform with excellent biocompatibility for the tumor-targeted co-delivery of various anti-cancer agents. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Low-Density Lipoprotein-Mimicking Nanoparticles for Tumor-Targeted Theranostic Applications | - |
dc.type | Article | - |
dc.identifier.wosid | 000347784000009 | - |
dc.identifier.scopusid | 2-s2.0-84920507456 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 222 | - |
dc.citation.endingpage | 231 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201303277 | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.localauthor | Nam, Yoon-Sung | - |
dc.contributor.nonIdAuthor | Kim, Youngwook | - |
dc.contributor.nonIdAuthor | Park, Keunchil | - |
dc.contributor.nonIdAuthor | Lee, Jung Hee | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | low-density lipoproteins | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | anti-cancer agents | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | imaging | - |
dc.subject.keywordPlus | MANGANESE OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IRON-OXIDE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | FORMULATION | - |
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