A selective, long-lived deep-red emissive ruthenium(II) polypyridine complexes for the detection of BSA
A selective, label free luminescence sensor for bovine serum albumin (BSA) is investigated using ruthenium(II) complexes over the other proteins. Interaction between BSA and ruthenium(II) complexes has been studied using absorption, emission, excited state lifetime and circular dichroism (CD) spectral techniques. The luminescence intensity of ruthenium(II) complexes (I and II), has enhanced at 602 and 613 nm with a large hypsochromic shift of 18 and 5 nm respectively upon addition of BSA. The mode of binding of ruthenium(II) complexes with BSA has analyzed using computational docking studies.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Issue Date
- 2014-09
- Language
- English
- Article Type
- Article
- Keywords
BOVINE SERUM-ALBUMIN; MOLECULAR LIGHT SWITCH; 3 RECOMBINANT DOMAINS; BINDING PROPERTIES; CRYSTAL-STRUCTURE; PROTEIN-BINDING; LIGAND-BINDING; FLUORESCENCE; RECOGNITION; PROBE
- Citation
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v.130, pp.553 - 560
- ISSN
- 1386-1425
- Appears in Collection
- RIMS Journal Papers
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