Generation of hierarchical nano- and microwrinkle structure for smooth muscle cell alignment

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On the contrary to the complicated and high-cost photolithography based topographical patterning, the non-lithographical strain responsive wrinkling method can generate a variety of wrinkle structures with ease, high uniformity, and cost-effectiveness. The strain responsive wrinkling approach relied on the modulus difference between a thin and stiff film and a soft substrate, resulting in a periodic out-of-plane buckling deformation upon the release of the compressive stress. While the previous reports were dedicated to the micropattern generation, we, in this study, investigated the effect of the UV/O exposure time (10, 20, 30, 40, 50, and 60 min) and the stretching rate (10, 20, 30, and 40%) of the PDMS substrate on the wavelength and the amplitude of the wrinkle patterns in details. Sole nanowrinkle as well as hierarchical nano/microwrinkle patterns could be fabricated through the fine control of those factors. Furthermore, we examined the human aortic smooth muscle cell (HASMCs) alignment on the topographical patterned surface, and found that more than 80% of the HASMCs were cultured and aligned well along with the hierarchical nano/microwrinkle rather than the nanowrinkle pattern.
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Issue Date
2014-03
Language
English
Article Type
Article
Keywords

TOPOGRAPHICAL CONTROL; THIN-FILMS; BEHAVIOR; SURFACES; POLYMER; CULTURE

Citation

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.19, no.2, pp.269 - 275

ISSN
1226-8372
DOI
10.1007/s12257-013-0740-3
URI
http://hdl.handle.net/10203/189326
Appears in Collection
CBE-Journal Papers(저널논문)
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