DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Ji-Hae | ko |
dc.contributor.author | Jung, Ye-Jin | ko |
dc.contributor.author | Mohamed, Mohamed Antar Aziz | ko |
dc.contributor.author | Lee, Tae Hoon | ko |
dc.contributor.author | Lee, Chang-Ho | ko |
dc.contributor.author | Han, Daeseok | ko |
dc.contributor.author | Song, Myung-Chong | ko |
dc.contributor.author | Kim, Jiyoung | ko |
dc.contributor.author | Baek, Nam-In | ko |
dc.date.accessioned | 2014-08-29T01:51:44Z | - |
dc.date.available | 2014-08-29T01:51:44Z | - |
dc.date.created | 2014-04-22 | - |
dc.date.created | 2014-04-22 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | HELVETICA CHIMICA ACTA, v.97, no.3, pp.438 - 446 | - |
dc.identifier.issn | 0018-019X | - |
dc.identifier.uri | http://hdl.handle.net/10203/188888 | - |
dc.description.abstract | Two new bisabolane sesquiterpenoids, 1 and 2, along with five known ones, 13-hydroxyxanthorrhizol (3), 12,13-epoxyxanthorrhizol (4), xanthorrhizol (5), beta-curcumene (6), and beta-bisabolol (7), were isolated from the rhizomes of Curcuma xanthorrhiza Roxb. The chemical structures of the new compounds were determined to be (7R,10R)-10,11-dihydro-10,11-dihydroxyxanthorrhizol 3-O-beta-D-glucopyranoside (1) and (-)-curcuhydroquinone 2,5-di-O-beta-D-glucopyranoside (2) on the basis of 1D- and 2D-NMR spectroscopic analyses and optical-rotation characteristics. Compounds 2 and 3 decreased MMP-1 expression in UVB-treated human keratinocytes by ca. 8.9- and 7.6-fold at the mRNA level, and by ca. 9.2- and 6.6-fold at the protein level, respectively. The results indicate that the isolated compounds may have anti-aging effects through inhibition of MMP-1 expression in skin cells. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | LONGA L. | - |
dc.subject | CONSTITUENTS | - |
dc.subject | HETEROPHYLLA | - |
dc.subject | FIBROBLASTS | - |
dc.subject | CANCER | - |
dc.title | New Bisabolane Sesquiterpenes from the Rhizomes of Curcuma xanthorrhiza Roxb. and Their Inhibitory Effects on UVB-Induced MMP-1 Expression in Human Keratinocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000332935000018 | - |
dc.identifier.scopusid | 2-s2.0-84896338562 | - |
dc.type.rims | ART | - |
dc.citation.volume | 97 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 438 | - |
dc.citation.endingpage | 446 | - |
dc.citation.publicationname | HELVETICA CHIMICA ACTA | - |
dc.identifier.doi | 10.1002/hlca.201300372 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Song, Myung-Chong | - |
dc.contributor.nonIdAuthor | Park, Ji-Hae | - |
dc.contributor.nonIdAuthor | Jung, Ye-Jin | - |
dc.contributor.nonIdAuthor | Mohamed, Mohamed Antar Aziz | - |
dc.contributor.nonIdAuthor | Lee, Tae Hoon | - |
dc.contributor.nonIdAuthor | Lee, Chang-Ho | - |
dc.contributor.nonIdAuthor | Han, Daeseok | - |
dc.contributor.nonIdAuthor | Kim, Jiyoung | - |
dc.contributor.nonIdAuthor | Baek, Nam-In | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | MMP-1 Expression | - |
dc.subject.keywordAuthor | (-)-Curcuhydroquinone 2,5-di-O-beta-D-glucopyranoside | - |
dc.subject.keywordAuthor | Anti-aging | - |
dc.subject.keywordAuthor | UV Irradiation | - |
dc.subject.keywordAuthor | Xanthorrhizol 3-O-beta-D-glucopyranoside, (7R,10R)-10,11-dihydro-10,11-dihydroxy- | - |
dc.subject.keywordPlus | LONGA L. | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | HETEROPHYLLA | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | CANCER | - |
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