DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Bora | ko |
dc.contributor.author | Jiao, Alex | ko |
dc.contributor.author | Yu, Seungjung | ko |
dc.contributor.author | You, Jae Bem | ko |
dc.contributor.author | Kim, Deok-Ho | ko |
dc.contributor.author | Im, Sung Gap | ko |
dc.date.accessioned | 2013-08-26T06:31:51Z | - |
dc.date.available | 2013-08-26T06:31:51Z | - |
dc.date.created | 2013-07-19 | - |
dc.date.created | 2013-07-19 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | ACTA BIOMATERIALIA, v.9, no.8, pp.7691 - 7698 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | http://hdl.handle.net/10203/176499 | - |
dc.description.abstract | Poly(N-vinylcaprolactam) (PNVCL) is a thermoresponsive polymer known to be nontoxic, water soluble and biocompatible. Here, PNVCL homopolymer was successfully synthesized for the first time by use of a one-step vapor-phase process, termed initiated chemical vapor deposition (iCVD). Fourier transform infrared spectroscopy results showed that radical polymerization took place from N-vinylcaprolactam monomers without damaging the functional caprolactam ring. A sharp lower critical solution temperature transition was observed at 31 degrees C from the iCVD poly(N-vinylcaprolactam) (PNVCL) film. The thermoresponsive PNVCL surface exhibited a hydrophilic/hydrophobic alteration with external temperature change, which enabled the thermally modulated attachment and detachment of cells. The conformal coverage of PNVCL film on various substrates with complex topography, including fabrics and nanopattems, was successfully demonstrated, which can further be utilized to fabricate cell sheets with aligned cell morphology. The advantage of this system is that cells cultured on such thermoresponsive surfaces could be recovered as an intact cell sheet by simply lowering the temperature, eliminating the need for conventional enzymatic treatments. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | THERMOSENSITIVE POLYMERS | - |
dc.subject | CARDIOMYOCYTE SHEETS | - |
dc.subject | RESPONSIVE POLYMERS | - |
dc.subject | CULTURE DISHES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | TEMPERATURE | - |
dc.subject | SURFACES | - |
dc.subject | POLY(N-VINYLCAPROLACTAM) | - |
dc.subject | DETACHMENT | - |
dc.subject | TISSUES | - |
dc.title | Initiated chemical vapor deposition of thermoresponsive poly (N-vinylcaprolactam) thin films for cell sheet engineering | - |
dc.type | Article | - |
dc.identifier.wosid | 000322207700009 | - |
dc.identifier.scopusid | 2-s2.0-84891688147 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 7691 | - |
dc.citation.endingpage | 7698 | - |
dc.citation.publicationname | ACTA BIOMATERIALIA | - |
dc.identifier.doi | 10.1016/j.actbio.2013.04.049 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Im, Sung Gap | - |
dc.contributor.nonIdAuthor | Lee, Bora | - |
dc.contributor.nonIdAuthor | Jiao, Alex | - |
dc.contributor.nonIdAuthor | Yu, Seungjung | - |
dc.contributor.nonIdAuthor | Kim, Deok-Ho | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Polymer | - |
dc.subject.keywordAuthor | Cell sheet engineering | - |
dc.subject.keywordAuthor | Thermoresponsive | - |
dc.subject.keywordAuthor | iCVD | - |
dc.subject.keywordPlus | THERMOSENSITIVE POLYMERS | - |
dc.subject.keywordPlus | CARDIOMYOCYTE SHEETS | - |
dc.subject.keywordPlus | RESPONSIVE POLYMERS | - |
dc.subject.keywordPlus | CULTURE DISHES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | POLY(N-VINYLCAPROLACTAM) | - |
dc.subject.keywordPlus | DETACHMENT | - |
dc.subject.keywordPlus | TISSUES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.