DC Field | Value | Language |
---|---|---|
dc.contributor.author | Muthiah, Muthunarayanan | ko |
dc.contributor.author | Lee, Sang Joon | ko |
dc.contributor.author | Moon, Myeongju | ko |
dc.contributor.author | Lee, Hyun Jin | ko |
dc.contributor.author | Bae, Woo Kyun | ko |
dc.contributor.author | Chung, Ik Joo | ko |
dc.contributor.author | Jeong, Yong Yeon | ko |
dc.contributor.author | Park, In-Kyu | ko |
dc.date.accessioned | 2013-08-08T06:04:02Z | - |
dc.date.available | 2013-08-08T06:04:02Z | - |
dc.date.created | 2013-07-03 | - |
dc.date.created | 2013-07-03 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.citation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.13, no.3, pp.1626 - 1630 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | http://hdl.handle.net/10203/174843 | - |
dc.description.abstract | Polymersomes with different surface charges were synthesized from polysuccinimide (p) by introducing positively charged polyethylenimine (PEI-P), neutrally charged polyethylene glycol (PEG-P), and negatively charged glycine (GLY-P) to the polymer backbone polysuccinimide (P). Then, the polymersomes were prepared with super paramagnetic iron nanoparticles (SPIONs) to obtain PEI-P encapsulating SPIONs (PEI-PS), PEG-P encapsulating SPIONs (PEG-PS), and GLY-P encapsulating SPIONs (GLY-PS), respectively. The average particle sizes of GLY-PS, PEG-PS, and PEI-PS were analyzed by dynamic light scattering, and it was around 163 nm, 105 nm, and 285 nm, respectively. The surface charges of GLY-PS, PEG-PS, and PEI-PS was found to be -29.5, -18.9, and +44, respectively. The presence of PEI, PEG, and GLY in the polymer backbone was confirmed with nuclear magnetic resonance (NMR). The GLY-PS, PEG-PS, and PEI-PS were loaded with the anticancer drug paclitaxel during the preparation. The drug release from the PEG-PS was faster compared to GLY-PS and PEI-PS. An in vivo hemi-spleen mouse metastatic liver model was established and imaged with MRI after intravenous administration of GLY-PS, PEG-PS, and PEI-PS. From the T2-weighted imaging, it was evident that PEG-PS accumulated in the spleen and liver more efficiently than the other charged formulations of GLY-PS and PEI-PS. From this study, the nanoparticle-based delivery and imaging of anti-cancer drugs could be effectively demonstrated simultaneously. | - |
dc.language | English | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.subject | GENE DELIVERY | - |
dc.subject | MICELLES | - |
dc.subject | NANOCARRIERS | - |
dc.title | Surface Tunable Polymersomes Loaded with Magnetic Contrast Agent and Drug for Image Guided Cancer Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000319027300002 | - |
dc.identifier.scopusid | 2-s2.0-84876223658 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 1626 | - |
dc.citation.endingpage | 1630 | - |
dc.citation.publicationname | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.identifier.doi | 10.1166/jnn.2013.6979 | - |
dc.contributor.localauthor | Lee, Hyun Jin | - |
dc.contributor.nonIdAuthor | Muthiah, Muthunarayanan | - |
dc.contributor.nonIdAuthor | Lee, Sang Joon | - |
dc.contributor.nonIdAuthor | Moon, Myeongju | - |
dc.contributor.nonIdAuthor | Bae, Woo Kyun | - |
dc.contributor.nonIdAuthor | Chung, Ik Joo | - |
dc.contributor.nonIdAuthor | Jeong, Yong Yeon | - |
dc.contributor.nonIdAuthor | Park, In-Kyu | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Multi-Functional | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | Drug Delivery | - |
dc.subject.keywordAuthor | Polymersomes | - |
dc.subject.keywordAuthor | SPION | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
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