Selective detection of cysteine over homocysteine and glutathione by a bis(bromoacetyl)fluorescein probe
A bromoacetyl functionalized fluorescein chemodosimeter (1) was utilized as a fluorescent probe for cysteine. The probe showed a selective and sensitive response to cysteine over homocysteine and glutathione in aqueous buffer through a rapid cyclization reaction. When cysteine was added, a fast fluorescence turn-on change of 1 was observed, thus allowing cysteine to be discriminated from other biothiols and micromolar concentrations of cysteine to be detected by the naked eye. (C) 2013 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Issue Date
- 2013-06
- Language
- English
- Article Type
- Article
- Keywords
TURN-ON PROBE; FLUORESCENCE; DISEASE; SENSOR
- Citation
TETRAHEDRON LETTERS, v.54, no.23, pp.3003 - 3006
- ISSN
- 0040-4039
- Appears in Collection
- RIMS Journal Papers
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- There are no files associated with this item.
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