LONG-TERM TEMPORAL CHANGES OF PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS BEFORE AND AFTER PANRETINAL PHOTOCOAGULATION IN SEVERE DIABETIC RETINOPATHY

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dc.contributor.authorKim, Jongshinko
dc.contributor.authorWoo, Se Joonko
dc.contributor.authorAhn, Jeeyunko
dc.contributor.authorPark, Ki Hoko
dc.contributor.authorChung, Humko
dc.contributor.authorPark, Kyu Hyungko
dc.date.accessioned2013-08-08T05:30:24Z-
dc.date.available2013-08-08T05:30:24Z-
dc.date.created2013-07-29-
dc.date.created2013-07-29-
dc.date.created2013-07-29-
dc.date.issued2012-11-
dc.identifier.citationRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, v.32, no.10, pp.2052 - 2060-
dc.identifier.issn0275-004X-
dc.identifier.urihttp://hdl.handle.net/10203/174469-
dc.description.abstractPurpose: To analyze the long-term changes of peripapillary retinal nerve fiber layer (RNFL) thickness before and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy. Methods: In this retrospective observational case series, we reviewed the records of 46 patients (68 eyes) with severe diabetic retinopathy, who were treated with PRP and could be followed for more than 6 months. Peripapillary RNFL thickness and foveal thickness were measured at baseline, 3-month intervals until 1 year post-PRP, and 6- to 12-month intervals after 1 year post-PRP using optical coherence tomography. Long-term changes of peripapillary RNFL thickness and foveal thickness as well as the correlation between the two parameters were analyzed. Results: The average RNFL thickness (360 degrees measurement) decreased significantly from 108.4 mu m to 103.5 mu m at 2 years post-PRP. The average RNFL thickness increased slightly during the initial 3 months post-PRP and thereafter gradually decreased, showing statistically significant reductions at 2 years post-PRP (false discovery rate adjusted P = 0.0051). The superior and inferior quadrant RNFL thicknesses were significantly decreased at 2 years post-PRP (false discovery rate adjusted P = 0.0119 and 0.0051, respectively). The decrease in the nasal quadrant RNFL thickness showed borderline significance at 2 years post-PRP (false discovery rate adjusted P = 0.0854). However, there was no significant decrease in RNFL thickness for the temporal quadrant at any follow-up time. In addition, there was no significant difference in the foveal thickness. But, the pattern of temporal changes in foveal thickness showed a similar pattern with that of temporal RNFL thickness. Conclusion: This study shows that average RNFL thickness after PRP undergoes early thickening and subsequent progressive thinning throughout the 2 years post-PRP. This temporal change varies according to the peripapillary RNFL quadrant. Our results also indicate that temporal RNFL and foveal thickness have a similar pattern of long-term change after PRP. RETINA 32: 2052-2060, 2012-
dc.languageEnglish-
dc.publisherLIPPINCOTT WILLIAMS WILKINS-
dc.subjectLASER PHOTOCOAGULATION-
dc.subjectGLAUCOMATOUS EYES-
dc.subjectREPRODUCIBILITY-
dc.subjectDAMAGE-
dc.subjectOCT-
dc.titleLONG-TERM TEMPORAL CHANGES OF PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS BEFORE AND AFTER PANRETINAL PHOTOCOAGULATION IN SEVERE DIABETIC RETINOPATHY-
dc.typeArticle-
dc.identifier.wosid000310520400010-
dc.identifier.scopusid2-s2.0-84871347875-
dc.type.rimsART-
dc.citation.volume32-
dc.citation.issue10-
dc.citation.beginningpage2052-
dc.citation.endingpage2060-
dc.citation.publicationnameRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES-
dc.identifier.doi10.1097/IAE.0b013e3182562000-
dc.contributor.localauthorKim, Jongshin-
dc.contributor.nonIdAuthorWoo, Se Joon-
dc.contributor.nonIdAuthorAhn, Jeeyun-
dc.contributor.nonIdAuthorPark, Ki Ho-
dc.contributor.nonIdAuthorChung, Hum-
dc.contributor.nonIdAuthorPark, Kyu Hyung-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorlong-term-
dc.subject.keywordAuthorretinal nerve fiber thickness-
dc.subject.keywordAuthorpanretinal photocoagulation-
dc.subject.keywordAuthordiabetic retinopathy-
dc.subject.keywordPlusLASER PHOTOCOAGULATION-
dc.subject.keywordPlusGLAUCOMATOUS EYES-
dc.subject.keywordPlusREPRODUCIBILITY-
dc.subject.keywordPlusDAMAGE-
dc.subject.keywordPlusOCT-
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