DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Yoon Sung | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-24T05:36:46Z | - |
dc.date.available | 2009-11-24T05:36:46Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, v.47, no.1, pp.8 - 17 | - |
dc.identifier.issn | 0021-9304 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13204 | - |
dc.description.abstract | Poly(L-lactic acid) and its copolymers with D-lactic and glycolic acid were used to fabricate various porous biodegradable scaffolds suitable for tissue engineering and drug delivery based on a thermally induced phase separation (TIPS) technique. A variety of parameters involved in TIPS process, such as types of polymers, polymer concentration, solvent/nonsolvent ratio, and quenching temperature, were examined in detail to produce a wide array of micro- and macroporous structures. A mixture of dioxane and water was used for a binary composition of solvent and nonsolvent, respectively In particular, the coarsening effect of pore enlargement affected by controlling the quenching temperature was used for the generation of a macroporous open cellular structure with pore diameters above 100 mu m. The use of amorphous polymers with a slow cooling rate resulted in a macroporous open cellular structure, whereas that of semicrystalline polymers with a fast cooling rate generated a microporous closed cellular structure. The fabricated porous devices loaded with recombinant human growth hormone (rhGH) were tested for the controlled delivery of rhGH, as a potential additional means to cell delivery. (C) 1999 John Wiley & Sons, Inc. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | JOHN WILEY & SONS INC | - |
dc.subject | MICROPOROUS MEMBRANE FORMATION | - |
dc.subject | POLY(L-LACTIC ACID) FOAMS | - |
dc.subject | SPINODAL DECOMPOSITION | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | MIXTURES | - |
dc.subject | SPONGES | - |
dc.title | Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation | - |
dc.type | Article | - |
dc.identifier.wosid | 000081599800002 | - |
dc.identifier.scopusid | 2-s2.0-0002969423 | - |
dc.type.rims | ART | - |
dc.citation.volume | 47 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 8 | - |
dc.citation.endingpage | 17 | - |
dc.citation.publicationname | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | - |
dc.identifier.doi | 10.1002/(SICI)1097-4636(199910)47:1<8::AID-JBM2>3.0.CO;2-L | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Nam, Yoon Sung | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | biodegradable polymer | - |
dc.subject.keywordAuthor | porous scaffolds | - |
dc.subject.keywordAuthor | thermally induced phase separation | - |
dc.subject.keywordPlus | MICROPOROUS MEMBRANE FORMATION | - |
dc.subject.keywordPlus | POLY(L-LACTIC ACID) FOAMS | - |
dc.subject.keywordPlus | SPINODAL DECOMPOSITION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MIXTURES | - |
dc.subject.keywordPlus | SPONGES | - |
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