Surface modification of poly(glycolic acid) (PGA) for biomedical applications

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dc.contributor.authorLee, KBko
dc.contributor.authorYoon, KRko
dc.contributor.authorWoo, Seong-Ihlko
dc.contributor.authorChoi, Insungko
dc.date.accessioned2009-11-23T01:06:45Z-
dc.date.available2009-11-23T01:06:45Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-05-
dc.identifier.citationJOURNAL OF PHARMACEUTICAL SCIENCES, v.92, no.5, pp.933 - 937-
dc.identifier.issn0022-3549-
dc.identifier.urihttp://hdl.handle.net/10203/13066-
dc.description.abstractThe immobilization of biological ligands (such as biotin and peptides) onto biodegradable polymer surfaces, including poly(glycolic acid) (PGA) sutures, is complicated by the absence of functional groups on the polymer backbone. We demonstrate a method for overcoming this problem, by attaching (+)-biotinyl-3,6,9-trioxaundecanediamine to the surface of PGA sutures, which immobilizes the ligand through an amide bond between amine (ligands) and carboxylic acid groups (surface-hydrolyzed PGA sutures). Fluorescence microscopy was used to verify the attachment of the biotin ligand to the surface of the PGA suture after a complexation with fluorescein-conjugated streptavidin. The strategy can be generalized to surface modifications of other biodegradable aliphatic polyesters, which would improve the properties of the polymers in biomedical applications such as active targeting of drugs based on ligand-attached, polymeric drug delvery systems. (C) 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherJOHN WILEY & SONS INC-
dc.subjectOSTEOBLAST IN-VITRO-
dc.subjectPOLY(LACTIC ACID-CO-LYSINE)-
dc.subjectPOLY(D,L-LACTIC ACID)-
dc.subjectSILK FIBROIN-
dc.subjectPEPTIDE-
dc.subjectCULTURE-
dc.subjectCELLS-
dc.titleSurface modification of poly(glycolic acid) (PGA) for biomedical applications-
dc.typeArticle-
dc.identifier.wosid000182632300002-
dc.identifier.scopusid2-s2.0-0037407350-
dc.type.rimsART-
dc.citation.volume92-
dc.citation.issue5-
dc.citation.beginningpage933-
dc.citation.endingpage937-
dc.citation.publicationnameJOURNAL OF PHARMACEUTICAL SCIENCES-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorWoo, Seong-Ihl-
dc.contributor.localauthorChoi, Insung-
dc.contributor.nonIdAuthorLee, KB-
dc.contributor.nonIdAuthorYoon, KR-
dc.type.journalArticleLetter-
dc.subject.keywordAuthoraliphatic polyesters-
dc.subject.keywordAuthorpoly(glycolic acid) (PGA)-
dc.subject.keywordAuthorsurface erosion-
dc.subject.keywordAuthorsurface modification-
dc.subject.keywordAuthorcovalent attachment-
dc.subject.keywordPlusOSTEOBLAST IN-VITRO-
dc.subject.keywordPlusPOLY(LACTIC ACID-CO-LYSINE)-
dc.subject.keywordPlusPOLY(D,L-LACTIC ACID)-
dc.subject.keywordPlusSILK FIBROIN-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordPlusCULTURE-
dc.subject.keywordPlusCELLS-
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