DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, KB | ko |
dc.contributor.author | Yoon, KR | ko |
dc.contributor.author | Woo, Seong-Ihl | ko |
dc.contributor.author | Choi, Insung | ko |
dc.date.accessioned | 2009-11-23T01:06:45Z | - |
dc.date.available | 2009-11-23T01:06:45Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-05 | - |
dc.identifier.citation | JOURNAL OF PHARMACEUTICAL SCIENCES, v.92, no.5, pp.933 - 937 | - |
dc.identifier.issn | 0022-3549 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13066 | - |
dc.description.abstract | The immobilization of biological ligands (such as biotin and peptides) onto biodegradable polymer surfaces, including poly(glycolic acid) (PGA) sutures, is complicated by the absence of functional groups on the polymer backbone. We demonstrate a method for overcoming this problem, by attaching (+)-biotinyl-3,6,9-trioxaundecanediamine to the surface of PGA sutures, which immobilizes the ligand through an amide bond between amine (ligands) and carboxylic acid groups (surface-hydrolyzed PGA sutures). Fluorescence microscopy was used to verify the attachment of the biotin ligand to the surface of the PGA suture after a complexation with fluorescein-conjugated streptavidin. The strategy can be generalized to surface modifications of other biodegradable aliphatic polyesters, which would improve the properties of the polymers in biomedical applications such as active targeting of drugs based on ligand-attached, polymeric drug delvery systems. (C) 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | JOHN WILEY & SONS INC | - |
dc.subject | OSTEOBLAST IN-VITRO | - |
dc.subject | POLY(LACTIC ACID-CO-LYSINE) | - |
dc.subject | POLY(D,L-LACTIC ACID) | - |
dc.subject | SILK FIBROIN | - |
dc.subject | PEPTIDE | - |
dc.subject | CULTURE | - |
dc.subject | CELLS | - |
dc.title | Surface modification of poly(glycolic acid) (PGA) for biomedical applications | - |
dc.type | Article | - |
dc.identifier.wosid | 000182632300002 | - |
dc.identifier.scopusid | 2-s2.0-0037407350 | - |
dc.type.rims | ART | - |
dc.citation.volume | 92 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 933 | - |
dc.citation.endingpage | 937 | - |
dc.citation.publicationname | JOURNAL OF PHARMACEUTICAL SCIENCES | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Woo, Seong-Ihl | - |
dc.contributor.localauthor | Choi, Insung | - |
dc.contributor.nonIdAuthor | Lee, KB | - |
dc.contributor.nonIdAuthor | Yoon, KR | - |
dc.type.journalArticle | Letter | - |
dc.subject.keywordAuthor | aliphatic polyesters | - |
dc.subject.keywordAuthor | poly(glycolic acid) (PGA) | - |
dc.subject.keywordAuthor | surface erosion | - |
dc.subject.keywordAuthor | surface modification | - |
dc.subject.keywordAuthor | covalent attachment | - |
dc.subject.keywordPlus | OSTEOBLAST IN-VITRO | - |
dc.subject.keywordPlus | POLY(LACTIC ACID-CO-LYSINE) | - |
dc.subject.keywordPlus | POLY(D,L-LACTIC ACID) | - |
dc.subject.keywordPlus | SILK FIBROIN | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | CELLS | - |
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