DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kang-Hoon | ko |
dc.contributor.author | You, Ri-Na | ko |
dc.contributor.author | Greenhalgh, David G. | ko |
dc.contributor.author | Cho, Kiho | ko |
dc.date.accessioned | 2013-03-13T05:18:46Z | - |
dc.date.available | 2013-03-13T05:18:46Z | - |
dc.date.created | 2013-01-22 | - |
dc.date.created | 2013-01-22 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | CHROMOSOME RESEARCH, v.20, no.7, pp.859 - 874 | - |
dc.identifier.issn | 0967-3849 | - |
dc.identifier.uri | http://hdl.handle.net/10203/104548 | - |
dc.description.abstract | About 10 % of the mouse genome is occupied by sequences associated with endogenous retroviruses (ERVs). However, a comprehensive profile of the mouse ERVs and related elements has not been established yet. In this study, we identified a group of ERVs from the mouse genome and characterized their biological properties. Using a custom ERV mining protocol, 191 ERVs (159 loci reported previously and 32 new loci), tentatively named Mus dunni endogenous virus (MDEV)-like ERVs (MDL-ERVs), were mapped on the C57BL/6J mouse genome. Seven of them retained putative full coding potentials for three retroviral polypeptides (gag, pol, and env). Among the 57 mouse strains examined, all but the Mus pahari/Ei strain had PCR amplicons corresponding to a conserved MDL-ERV region. Interestingly, the Mus caroli/EiJ's amplicon was somewhat larger than the others, coinciding with a substantial phylogenetic distance between the MDL-ERV populations of M. caroli/EiJ and C57BL/6J strains. MDL-ERVs were highly expressed in the lung, spleen, and thymus of C57BL/6J mice compared to the brain, heart, kidney, and liver. Seven MDL-ERVs were mapped in the introns of six annotated genes. Of interest, some MDL-ERVs were mapped periodically on three clusters in chromosome X. The finding that these MDL-ERVs were one of several types of retroelements, which form mosaic-repeat units of tandem arrays, suggests that the formation of the mosaic-repeat unit preceded the tandem arrangement event. Further studies are warranted to understand the biological roles of MDL-ERVs in both normal and pathologic conditions. | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | 30S RNA | - |
dc.subject | EVOLUTION | - |
dc.subject | MICE | - |
dc.subject | SEQUENCE | - |
dc.subject | ELEMENTS | - |
dc.subject | REVEALS | - |
dc.subject | CLONING | - |
dc.subject | FAMILY | - |
dc.subject | CELLS | - |
dc.subject | ERV | - |
dc.title | Identification of a group of Mus dunni endogenous virus-like endogenous retroviruses from the C57BL/6J mouse genome: proviral genomes, strain distribution, expression characteristics, and genomic integration profile | - |
dc.type | Article | - |
dc.identifier.wosid | 000312632500005 | - |
dc.identifier.scopusid | 2-s2.0-84875886858 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 859 | - |
dc.citation.endingpage | 874 | - |
dc.citation.publicationname | CHROMOSOME RESEARCH | - |
dc.identifier.doi | 10.1007/s10577-012-9322-z | - |
dc.contributor.localauthor | You, Ri-Na | - |
dc.contributor.nonIdAuthor | Lee, Kang-Hoon | - |
dc.contributor.nonIdAuthor | Greenhalgh, David G. | - |
dc.contributor.nonIdAuthor | Cho, Kiho | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | MDEV-like ERVs | - |
dc.subject.keywordAuthor | Expression | - |
dc.subject.keywordAuthor | Genome organization | - |
dc.subject.keywordAuthor | Gammaretrovirus-like ERVs | - |
dc.subject.keywordPlus | 30S RNA | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | ELEMENTS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ERV | - |
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