Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons

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Nigral dopamine (DA) neurons in vivo exhibit complex firing patterns consisting of tonic single-spikes and phasic bursts that encode information for certain types of reward-related learning and behavior. Non-linear dynamical analysis has previously demonstrated the presence of a non-linear deterministic structure in complex firing patterns of DA neurons, yet the origin of this non-linear determinism remains unknown. In this study, we hypothesized that bursting activity is the primary source of non-linear determinism in the firing patterns of DA neurons. To test this hypothesis, we investigated the dimension complexity of inter-spike interval data recorded in vivo from bursting and non-bursting DA neurons in the chloral hydrate-anesthetized rat substantia nigra. We found that bursting DA neurons exhibited non-linear determinism in their firing patterns, whereas non-bursting DA neurons showed truly stochastic firing patterns. Determinism was also detected in the isolated burst and inter-burst interval data extracted from firing patterns of bursting neurons. Moreover, less bursting DA neurons in halothane-anesthetized rats exhibited higher dimensional spiking dynamics than do more bursting DA neurons in chloral hydrate-anesthetized rats. These results strongly indicate that bursting activity is the main source of low-dimensional, non-linear determinism in the firing patterns of DA neurons. This finding furthermore suggests that bursts are the likely carriers of meaningful information in the firing activities of DA neurons.
Publisher
WILEY-BLACKWELL
Issue Date
2012-11
Language
English
Article Type
Article
Keywords

METHYL-D-ASPARTATE; SEQUENCE-DEPENDENT STRUCTURE; IN-VIVO; EXTRACELLULAR DOPAMINE; INTERSPIKE INTERVALS; GENERAL-ANESTHETICS; AFFERENT MODULATION; NEURAL INFORMATION; STRANGE ATTRACTORS; GLYCINE RECEPTORS

Citation

EUROPEAN JOURNAL OF NEUROSCIENCE, v.36, no.9, pp.3214 - 3223

ISSN
0953-816X
DOI
10.1111/j.1460-9568.2012.08238.x
URI
http://hdl.handle.net/10203/104521
Appears in Collection
BiS-Journal Papers(저널논문)
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