Recent advances in reconstruction and applications of genome-scale metabolic models

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In the last decade, reconstruction and applications of genome-scale metabolic models have greatly influenced the field of systems biology by providing a platform on which high-throughput computational analysis of metabolic networks can be performed. The last two years have seen an increase in volume of more than 33% in the number of published genome-scale metabolic models, signifying a high demand for these metabolic models in studying specific organisms. The diversity in modeling different types of cells, from photosynthetic microorganisms to human cell types, also demonstrates their growing influence in biology. Here we review the recent advances and current state of genome-scale metabolic models, the methods employed towards ensuring high quality models, their biotechnological applications, and the progress towards the automated reconstruction of genome-scale metabolic models.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2012-08
Language
English
Article Type
Review
Citation

CURRENT OPINION IN BIOTECHNOLOGY, v.23, no.4, pp.617 - 623

ISSN
0958-1669
DOI
10.1016/j.copbio.2011.10.007
URI
http://hdl.handle.net/10203/102981
Appears in Collection
CBE-Journal Papers(저널논문)
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