Improved influenza vaccination in the skin using vaccine coated microneedles

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Easy and effective vaccination methods could reduce mortality rates and morbidity due to vaccine-preventable influenza infections. In this study, we examined the use of microneedle patches to increase patient coverage through possible self-administration and enhance vaccine immunogenicity by targeted delivery to skin. We carried out a detailed study of protective immune responses after a single influenza vaccination to the skin of mice with a novel microneedle patch designed to facilitate simple and reliable vaccine delivery. Skin vaccination with inactivated virus-coated microneedles provided superior protection against lethal challenge compared to intramuscular injection as evidenced by effective virus clearance in lungs. Detailed immunologic analysis suggests that induction of virus neutralizing antibodies as well as enhanced anammestic humoral and cellular responses contributed to improved protection by microneedle vaccination to the skin. These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines. (C) 2009 Elsevier Ltd. All rights reserved.
Publisher
ELSEVIER SCI LTD
Issue Date
2009-11
Language
English
Article Type
Article
Keywords

RANDOMIZED CONTROLLED SAFETY; HEALTHY-ADULTS; TRANSCUTANEOUS IMMUNIZATION; MICROINJECTION SYSTEM; IMMUNOGENICITY TRIAL; DELIVERY; VIRUS; ARRAYS; MICE; TECHNOLOGY

Citation

VACCINE, v.27, no.49, pp.6932 - 6938

ISSN
0264-410X
DOI
10.1016/j.vaccine.2009.08.108
URI
http://hdl.handle.net/10203/101927
Appears in Collection
CBE-Journal Papers(저널논문)
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