DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, YoonSung | ko |
dc.contributor.author | Kim, Jin-Woong | ko |
dc.contributor.author | Park, JaeYoon | ko |
dc.contributor.author | Shim, Jongwon | ko |
dc.contributor.author | Lee, Jong Suk | ko |
dc.contributor.author | Han, Sang Hoon | ko |
dc.date.accessioned | 2013-03-12T01:29:32Z | - |
dc.date.available | 2013-03-12T01:29:32Z | - |
dc.date.created | 2012-05-29 | - |
dc.date.created | 2012-05-29 | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.94, pp.51 - 57 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | http://hdl.handle.net/10203/100964 | - |
dc.description.abstract | Tocopheryl acetate is used as the oil component of nanoemulsions using a mixture of unsaturated phospholipids and polyethylene oxide-block-poly(epsilon-caprolactone) (PEO-b-PCL). This study investigates the effects of the lipid-polymer composition on the size and surface charge of nanoemulsions, microviscosity of the interfacial layer, and skin absorption of tocopheryl acetate. The lipid-polymer hybrid system exhibits excellent colloidal dispersion stability, which is comparable to that of polymer-based nanoemulsions. If lipids are used as emulsifiers, nanoemulsions show poor dispersion stability despite a good skin absorption enhancing effect. The amount of tocopheryl acetate absorbed by the skin increases with an increased lipid-to-polymer ratio, as determined using the hairless guinea pig skin loaded in a Franz-type diffusion cell. An 8:2 (w/w) mixture of unsaturated phospholipids and PEO-b-PCL exhibits the most efficient delivery of tocopheryl acetate into the skin. Our results show that tocopheryl acetate is absorbed almost twice as fast by the lipid-polymer hybrid system than the nanoemulsions stabilized with PEO-b-PCL. This study suggests that the lipid-polymer hybrid system can be used as an effective means of optimizing nanoemulsions in terms of dispersion stability and skin delivery capability. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | PERCUTANEOUS PENETRATION | - |
dc.subject | NANO-EMULSIONS | - |
dc.subject | GUINEA-PIGS | - |
dc.subject | VITAMIN-E | - |
dc.subject | IN-VITRO | - |
dc.subject | FORMULATION | - |
dc.subject | PHOSPHOLIPIDS | - |
dc.subject | SURFACTANTS | - |
dc.subject | PERMEATION | - |
dc.subject | SUNSCREENS | - |
dc.title | Tocopheryl acetate nanoemulsions stabilized with lipid-polymer hybrid emulsifiers for effective skin delivery | - |
dc.type | Article | - |
dc.identifier.wosid | 000302979900008 | - |
dc.identifier.scopusid | 2-s2.0-84862826862 | - |
dc.type.rims | ART | - |
dc.citation.volume | 94 | - |
dc.citation.beginningpage | 51 | - |
dc.citation.endingpage | 57 | - |
dc.citation.publicationname | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.identifier.doi | 10.1016/j.colsurfb.2012.01.016 | - |
dc.contributor.localauthor | Nam, YoonSung | - |
dc.contributor.nonIdAuthor | Kim, Jin-Woong | - |
dc.contributor.nonIdAuthor | Shim, Jongwon | - |
dc.contributor.nonIdAuthor | Lee, Jong Suk | - |
dc.contributor.nonIdAuthor | Han, Sang Hoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Nanoemulsions | - |
dc.subject.keywordAuthor | Biodegradable polymers | - |
dc.subject.keywordAuthor | Polymeric emulsifiers | - |
dc.subject.keywordAuthor | Phospholipids | - |
dc.subject.keywordAuthor | Skin drug delivery | - |
dc.subject.keywordPlus | PERCUTANEOUS PENETRATION | - |
dc.subject.keywordPlus | NANO-EMULSIONS | - |
dc.subject.keywordPlus | GUINEA-PIGS | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | PHOSPHOLIPIDS | - |
dc.subject.keywordPlus | SURFACTANTS | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | SUNSCREENS | - |
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