Effect of microneedle on the pharmacokinetics of ketoprofen from its transdermal formulations

Cited 35 time in webofscience Cited 0 time in scopus
  • Hit : 357
  • Download : 0
Non-invasive transdermal delivery using microneedle arrays was recently introduced to deliver a variety of large and hydrophilic compounds into the skin, including proteins and DNA. In this study, a microneedle array was applied to the delivery of a hydrophobic drug, ketoprofen, to determine if transdermal delivery in rats can be improved without the need for permeation enhancers. The ability of a microneedle to increase the skin permeability of ketoprofen was tested using the following procedure. A microneedle array was inserted into the lower back skin of a rat using a clip for 10 min. Subsequently, 24mg/kg of a ketoprofen gel was loaded on the same site where the microneedle had been applied. Simultaneously, the microneedle was coated with 24mg/kg of a ketoprofen gel, and inserted into the skin using a clip for 10 min. As a negative control experiment, only 24mg/kg of the ketoprofen gel was applied to the shaved lower back of a rat. Blood samples were taken at the indicated times. The plasma concentration (C(p)) was obtained as a function of time (t), and the pharmacokinetic parameters were calculated using the BE program. The group loaded with the microneedle coated with ketoprofen gel showed a 1.86-fold and 2.86-fold increase in the AUC and C(max) compared with the ketoprofen gel alone group. These results suggest that a microneedle can be an ideal tool for transdermal delivery products.
Publisher
TAYLOR FRANCIS INC
Issue Date
2009
Language
English
Article Type
Article
Keywords

VITRO TRANSCUTANEOUS DELIVERY; SIMPLE GEL FORMULATIONS; IN-VITRO; DRUG-DELIVERY; GENE DELIVERY; SKIN; PERMEATION; DISEASE

Citation

DRUG DELIVERY, v.16, no.1, pp.52 - 56

ISSN
1071-7544
DOI
10.1080/10717540802518082
URI
http://hdl.handle.net/10203/100445
Appears in Collection
ME-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 35 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0