DC Field | Value | Language |
---|---|---|
dc.contributor.author | So, Jae-Woo | ko |
dc.contributor.author | Park, Hyoun-Hyang | ko |
dc.contributor.author | Lee, Seung Seob | ko |
dc.contributor.author | Kim, Dong-Chool | ko |
dc.contributor.author | Shin, Sang-Chul | ko |
dc.contributor.author | Cho, Cheong-Weon | ko |
dc.date.accessioned | 2013-03-11T22:04:24Z | - |
dc.date.available | 2013-03-11T22:04:24Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | DRUG DELIVERY, v.16, no.1, pp.52 - 56 | - |
dc.identifier.issn | 1071-7544 | - |
dc.identifier.uri | http://hdl.handle.net/10203/100445 | - |
dc.description.abstract | Non-invasive transdermal delivery using microneedle arrays was recently introduced to deliver a variety of large and hydrophilic compounds into the skin, including proteins and DNA. In this study, a microneedle array was applied to the delivery of a hydrophobic drug, ketoprofen, to determine if transdermal delivery in rats can be improved without the need for permeation enhancers. The ability of a microneedle to increase the skin permeability of ketoprofen was tested using the following procedure. A microneedle array was inserted into the lower back skin of a rat using a clip for 10 min. Subsequently, 24mg/kg of a ketoprofen gel was loaded on the same site where the microneedle had been applied. Simultaneously, the microneedle was coated with 24mg/kg of a ketoprofen gel, and inserted into the skin using a clip for 10 min. As a negative control experiment, only 24mg/kg of the ketoprofen gel was applied to the shaved lower back of a rat. Blood samples were taken at the indicated times. The plasma concentration (C(p)) was obtained as a function of time (t), and the pharmacokinetic parameters were calculated using the BE program. The group loaded with the microneedle coated with ketoprofen gel showed a 1.86-fold and 2.86-fold increase in the AUC and C(max) compared with the ketoprofen gel alone group. These results suggest that a microneedle can be an ideal tool for transdermal delivery products. | - |
dc.language | English | - |
dc.publisher | TAYLOR FRANCIS INC | - |
dc.subject | VITRO TRANSCUTANEOUS DELIVERY | - |
dc.subject | SIMPLE GEL FORMULATIONS | - |
dc.subject | IN-VITRO | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | GENE DELIVERY | - |
dc.subject | SKIN | - |
dc.subject | PERMEATION | - |
dc.subject | DISEASE | - |
dc.title | Effect of microneedle on the pharmacokinetics of ketoprofen from its transdermal formulations | - |
dc.type | Article | - |
dc.identifier.wosid | 000266057200008 | - |
dc.identifier.scopusid | 2-s2.0-70349572271 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 52 | - |
dc.citation.endingpage | 56 | - |
dc.citation.publicationname | DRUG DELIVERY | - |
dc.identifier.doi | 10.1080/10717540802518082 | - |
dc.contributor.localauthor | Lee, Seung Seob | - |
dc.contributor.nonIdAuthor | So, Jae-Woo | - |
dc.contributor.nonIdAuthor | Kim, Dong-Chool | - |
dc.contributor.nonIdAuthor | Shin, Sang-Chul | - |
dc.contributor.nonIdAuthor | Cho, Cheong-Weon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Microneedle | - |
dc.subject.keywordAuthor | Ketoprofen | - |
dc.subject.keywordAuthor | Gel | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.subject.keywordPlus | VITRO TRANSCUTANEOUS DELIVERY | - |
dc.subject.keywordPlus | SIMPLE GEL FORMULATIONS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | DISEASE | - |
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