DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, Hee Jeong | ko |
dc.contributor.author | Moon, Ji-Young | ko |
dc.contributor.author | Nam, Bo-Hye | ko |
dc.contributor.author | Kim, Young-Ok | ko |
dc.contributor.author | Kim, Woo-Jin | ko |
dc.contributor.author | Lee, Jeong-Ho | ko |
dc.contributor.author | Kim, Kyung-Kil | ko |
dc.contributor.author | Kim, Bong-Seok | ko |
dc.contributor.author | Yeo, Sang-Yeob | ko |
dc.contributor.author | Lee, Chang Hoon | ko |
dc.contributor.author | Kang, Kwang-Il | ko |
dc.contributor.author | Lee, Sang-Jun | ko |
dc.date.accessioned | 2013-03-11T20:17:52Z | - |
dc.date.available | 2013-03-11T20:17:52Z | - |
dc.date.created | 2012-05-17 | - |
dc.date.created | 2012-05-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | FISH & SHELLFISH IMMUNOLOGY, v.31, no.2, pp.189 - 195 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | http://hdl.handle.net/10203/100164 | - |
dc.description.abstract | Autophagy is an important cellular response to starvation and stress, and plays critical roles in embryogenesis, development, cell death, cancer, and immunity. Beclin-1 is one of the central regulators of autophagy in mammals. In the present study, we isolated a PoBeclin-1 cDNA from the olive flounder (Paralichthys olivaceus) by screening a flounder gill cDNA library and rapid amplification of cDNA ends (RACE). The PoBeclin-1 cDNA we isolated encodes a 447-amino acid polypeptide containing a conserved Bcl-2-binding domain. The deduced amino acid sequence of PoBeclin-1 showed high degrees of sequence identity (80.5-95.3%) with Beclin-1 from human, frog, mouse, zebrafish, and pufferfish. PoBeclin-1 transcripts were detected from 1 day post-hatching and were found to be ubiquitously expressed in the healthy flounder. Expression of PoBeclin-1 mRNA was increased in the kidney and spleen of flounders challenged with viral hemorrhagic septicemia virus (VHSV). When infected with VHSV, PoBeclin-1-overexpressing HINAE cells had low level (about 26%) of VHSV G transcripts compared to control cells. Taken together, these results suggest that PoBeclin-1 may play a role in the innate immune response to viral infection in the flounder. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | ADAPTIVE IMMUNITY | - |
dc.subject | SELF-DIGESTION | - |
dc.subject | CELL-DEATH | - |
dc.subject | C-ELEGANS | - |
dc.subject | PROTEIN | - |
dc.subject | MECHANISMS | - |
dc.subject | INNATE | - |
dc.subject | VIRUS | - |
dc.subject | DEGRADATION | - |
dc.title | Molecular characterization of the autophagy-related gene Beclin-1 from the olive flounder (Paralichthys olivaceus) | - |
dc.type | Article | - |
dc.identifier.wosid | 000293204500003 | - |
dc.identifier.scopusid | 2-s2.0-79959805124 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 189 | - |
dc.citation.endingpage | 195 | - |
dc.citation.publicationname | FISH & SHELLFISH IMMUNOLOGY | - |
dc.contributor.nonIdAuthor | Kong, Hee Jeong | - |
dc.contributor.nonIdAuthor | Moon, Ji-Young | - |
dc.contributor.nonIdAuthor | Nam, Bo-Hye | - |
dc.contributor.nonIdAuthor | Kim, Young-Ok | - |
dc.contributor.nonIdAuthor | Kim, Woo-Jin | - |
dc.contributor.nonIdAuthor | Lee, Jeong-Ho | - |
dc.contributor.nonIdAuthor | Kim, Kyung-Kil | - |
dc.contributor.nonIdAuthor | Kim, Bong-Seok | - |
dc.contributor.nonIdAuthor | Yeo, Sang-Yeob | - |
dc.contributor.nonIdAuthor | Lee, Chang Hoon | - |
dc.contributor.nonIdAuthor | Lee, Sang-Jun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Beclin-1 | - |
dc.subject.keywordAuthor | Autophagy-related gene | - |
dc.subject.keywordAuthor | Paralichthys olivaceus | - |
dc.subject.keywordAuthor | Viral hemorrhagic septicemia virus (VHSV) | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | ADAPTIVE IMMUNITY | - |
dc.subject.keywordPlus | SELF-DIGESTION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DEGRADATION | - |
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