DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposis sarcoma-associated herpesvirus latent replication

Cited 14 time in webofscience Cited 0 time in scopus
  • Hit : 319
  • Download : 0
During latent infection, latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays important roles in episomal persistence and replication. Several host factors are associated with KSHV latent replication. Here, we show that the catalytic subunit of DNA protein kinase (DNA-PKcs), Ku70, and Ku86 bind the N-terminal region of LANA. LANA was phosphorylated by DNA-PK and overexpression of Ku70, but not Ku86, impaired transient replication. The efficiency of transient replication was significantly increased in the HCT116 (Ku86 +/-) cell line, compared to the HCT116 (Ku86 +/+) cell line, suggesting that the DNA-PK/Ku complex negatively regulates KSHV latent replication. (C) 2010 Elsevier Inc. All rights reserved.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2010-04
Language
English
Article Type
Article
Keywords

DEPENDENT PROTEIN-KINASE; V(D)J RECOMBINATION; CARBOXY-TERMINUS; VIRAL GENOME; SEQUENCES; KSHV; IDENTIFICATION; REGIONS; VIRUS; KU80

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.394, no.4, pp.934 - 939

ISSN
0006-291X
DOI
10.1016/j.bbrc.2010.03.086
URI
http://hdl.handle.net/10203/94863
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 14 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0