A mesoporous silica functionalized by a covalently bound pyridine derivative for selective optical sensing of thymidine

Abstract

Fluorescent receptor 1 immobilized mesoporous silica (FMS) possessing the diaminopyridine moiety as a fluorescent receptor was fabricated by sol-gel reaction. The binding ability of FMS with nuclobases was evaluated by fluorophotometry. Interestingly, among nucleobases, addition of thymidine to a suspension of FMS in water resulted in the largest decrease in fluorescence intensity of diaminopyridine in FMS. These results indicate that FMS recognizes selectively thymidine in nucleobase. (C) 2007 Elsevier B.V. All rights reserved.