DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liou, J | ko |
dc.contributor.author | Kim, ML | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Jones, JT | ko |
dc.contributor.author | Myers, JW | ko |
dc.contributor.author | Ferrell, JE | ko |
dc.contributor.author | Meyer, T | ko |
dc.date.accessioned | 2013-03-07T14:43:39Z | - |
dc.date.available | 2013-03-07T14:43:39Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-07 | - |
dc.identifier.citation | CURRENT BIOLOGY, v.15, no.13, pp.1235 - 1241 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90421 | - |
dc.description.abstract | Ca2+ signaling in nonexcitable cells is typically initiated by receptor-triggered production of inositol-1,4,5-tris-phosphate and the release of Ca2+ from intracellular stores [1]. An elusive signaling process senses the Ca2+ store depletion and triggers the opening of plasma membrane Ca2+ channels [2-5]. The resulting sustained Ca2+ signals are required for many physiological responses, such as T cell activation and differentiation [6]. Here, we monitored receptor-triggered Ca2+ signals in cells transfected with siRNAs against 2,304 human signaling proteins, and we identified two proteins required for Ca2+-store-depletion-mediated Ca2+ influx, STIM1 and STIM2 [7-9]. These proteins have a single transmembrane region with a putative Ca2+ binding domain in the lumen of the endoplasmic reticulum. Ca2+ store depletion led to a rapid translocation of STIM1 into puncta that accumulated near the plasma membrane. Introducing a point mutation in the STIM1 Ca2+ binding domain resulted in prelocalization of the protein in puncta, and this mutant failed to respond to store depletion. Our study suggests that STIM proteins function as Ca2+ store sensors in the signaling pathway connecting Ca2+ store depletion to Ca2+ influx. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx | - |
dc.type | Article | - |
dc.identifier.wosid | 000230662400030 | - |
dc.identifier.scopusid | 2-s2.0-21844432686 | - |
dc.type.rims | ART | - |
dc.citation.volume | 15 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 1235 | - |
dc.citation.endingpage | 1241 | - |
dc.citation.publicationname | CURRENT BIOLOGY | - |
dc.identifier.doi | 10.1016/j.cub.2005.05.055 | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Liou, J | - |
dc.contributor.nonIdAuthor | Kim, ML | - |
dc.contributor.nonIdAuthor | Jones, JT | - |
dc.contributor.nonIdAuthor | Myers, JW | - |
dc.contributor.nonIdAuthor | Ferrell, JE | - |
dc.contributor.nonIdAuthor | Meyer, T | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CALCIUM-ENTRY | - |
dc.subject.keywordPlus | HELA-CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PROTEINS | - |
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