Dynamic surface tension of stable air-filled microbubbles prepared by freeze-drying a solution of lipid/surfactant mixture

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We studied the equilibrium and dynamic adsorption properties of the suspension solutions prepared from a mixture of 1-alpha-dipalmitoyl-phosphatidylcholine (DPPC), dicetyl phosphate (DCP), and Tyloxapol. Freeze-drying of suspension solutions significantly affects the dynamic behavior of DPPC, DCP, and Tyloxapol molecules at the air-water interface. Short time and long-time adsorption data obtained by maximum bubble pressure method show that Tyloxapol in a freeze-dried sample is preferentially adsorbed at the air-water interface, and a self-assembled structure in a freeze-dried sample (microbubble-rich) is much more stable than that of a non-freeze-dried sample (liposome-rich). (c) 2006 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2006-08
Language
English
Article Type
Article; Proceedings Paper
Keywords

ULTRASOUND CONTRAST AGENT; STABILIZED MICROBUBBLES; LANGMUIR TROUGH; ADSORPTION; INTERFACE; DIPALMITOYLPHOSPHATIDYLCHOLINE; ENHANCEMENT; DISPERSIONS; NANOBUBBLES; LIPOSOMES

Citation

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v.284, pp.453 - 457

ISSN
0927-7757
URI
http://hdl.handle.net/10203/88950
Appears in Collection
CBE-Journal Papers(저널논문)
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