In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila

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p53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation-induced apoptosis and reaper induction. These results indicate that Dmp53 is a central component of DNA damage-dependent apoptotic signaling. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Publisher
Elsevier Science Bv
Issue Date
2003-08
Language
ENG
Article Type
Article
Keywords

TUMOR-SUPPRESSOR P53; CHECKPOINT; CHK2; ACTIVATION; MUTATIONS; CANCER; GENE; HOMOLOG; PROTEIN; REAPER

Citation

FEBS LETTERS, v.550, no.1, pp.5 - 10

ISSN
0014-5793
URI
http://hdl.handle.net/10203/8290
Appears in Collection
BS-Journal Papers(저널논문)
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