DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Junsoo | ko |
dc.contributor.author | Seo, Taegun | ko |
dc.contributor.author | Hwang, Seungmin | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Gwack, Yousang | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-02T17:52:10Z | - |
dc.date.available | 2013-03-02T17:52:10Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-12 | - |
dc.identifier.citation | JOURNAL OF VIROLOGY, v.74, no.24, pp.11977 - 11982 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10203/74799 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53. | - |
dc.language | English | - |
dc.publisher | Amer Soc Microbiology | - |
dc.subject | EPSTEIN-BARR-VIRUS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | DNA-SEQUENCES | - |
dc.subject | VIRAL-DNA | - |
dc.subject | BZLF1 | - |
dc.subject | PROMOTER | - |
dc.subject | GROWTH | - |
dc.subject | BINDS | - |
dc.subject | AP-1 | - |
dc.subject | ZTA | - |
dc.title | The K-bZIP Protein from Kaposis Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional activity | - |
dc.type | Article | - |
dc.identifier.wosid | 000170365900063 | - |
dc.identifier.scopusid | 2-s2.0-0034467970 | - |
dc.type.rims | ART | - |
dc.citation.volume | 74 | - |
dc.citation.issue | 24 | - |
dc.citation.beginningpage | 11977 | - |
dc.citation.endingpage | 11982 | - |
dc.citation.publicationname | JOURNAL OF VIROLOGY | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Park, Junsoo | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.contributor.nonIdAuthor | Hwang, Seungmin | - |
dc.contributor.nonIdAuthor | Gwack, Yousang | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DNA-SEQUENCES | - |
dc.subject.keywordPlus | VIRAL-DNA | - |
dc.subject.keywordPlus | BZLF1 | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | BINDS | - |
dc.subject.keywordPlus | AP-1 | - |
dc.subject.keywordPlus | ZTA | - |
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