Synthesis of ketones with alkyl phosphonates and nitriles as acyl cation equivalent: Application of dephosphonylation reaction of beta-functionalized phosphonate with hydride
The preparation of several alpha-substituted ketones is performed in a one-pot procedure with alkyl phosphonates and aromatic nitriles by subsequent treatment of LiAlH4. A new method for nitriles used as an acyl cation equivalent is described.