A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction
A convenient procedure for preparation of the title compound of greater than or equal to 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Issue Date
- 1996-12
- Language
- English
- Article Type
- Article
- Keywords
OPTICALLY-ACTIVE OFLOXACIN; ANTIBACTERIAL ACTIVITIES; CHEMISTRY; YEAST
- Citation
TETRAHEDRON LETTERS, v.37, no.52, pp.9317 - 9320
- ISSN
- 0040-4039
- Appears in Collection
- Files in This Item
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