A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

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A convenient procedure for preparation of the title compound of greater than or equal to 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
1996-12
Language
English
Article Type
Article
Keywords

OPTICALLY-ACTIVE OFLOXACIN; ANTIBACTERIAL ACTIVITIES; CHEMISTRY; YEAST

Citation

TETRAHEDRON LETTERS, v.37, no.52, pp.9317 - 9320

ISSN
0040-4039
DOI
10.1016/S0040-4039(97)82952-8
URI
http://hdl.handle.net/10203/67709
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