DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박인철 | ko |
dc.contributor.author | 이판종 | ko |
dc.contributor.author | 양지원 | ko |
dc.contributor.author | 김종득 | ko |
dc.contributor.author | 최태부 | ko |
dc.date.accessioned | 2013-02-25T23:36:15Z | - |
dc.date.available | 2013-02-25T23:36:15Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1994-03 | - |
dc.identifier.citation | 한국미생물·생명공학회지 , v.22, no.3, pp.290 - 295 | - |
dc.identifier.issn | 1598-642X | - |
dc.identifier.uri | http://hdl.handle.net/10203/66045 | - |
dc.description.abstract | Micelle, liposome and polyethylene glycol(PEG) were employed to reduce the cell mem- brane toxicity of Amphotericin B(Amp. B). Cholesterol-sulfate which can form a mixed micelle with Amp. B molecules was found very effective for the reduction of Amp. B toxicity. 0.01% of cholesterol-sulfate could reduce the toxicity of 5X 10$^{-6}$ M Amp. B by 90%. The required concent- ration of cholesterol-sulfate for the toxicity reduction was proportionally increased with increasing Amp. B concentration. PEG was also effective on the reduction of Amp. B toxicity. 2% PEG was required for the reduction of toxicity by 50%, regardless of Amp. B concentration. The liposome system showed an effective reduction of Amp. B toxicity on RBC, maintaining the antibiotic effect on Candida albicans as free drugs. This seems to be due to the fact that liposome bilayer plays a role of buffer system between ergosterol of fungi cell membrane and cholesterol of red blood cell membrane, which leads the redistribution of Amp. B between them, as the result, the reduction of drug toxicity on cell membrane. | - |
dc.language | Korean | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | Micelle, Liposome, Polythylene Glycol을 이용한 Amphotericin B의 세포막 독성저하 | - |
dc.title.alternative | Reduction of Cell Membrane Toxicity of Amphotericin B Using Micelle,Liposome and Polyethyene Glycol | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 290 | - |
dc.citation.endingpage | 295 | - |
dc.citation.publicationname | 한국미생물·생명공학회지 | - |
dc.contributor.localauthor | 양지원 | - |
dc.contributor.localauthor | 김종득 | - |
dc.contributor.nonIdAuthor | 박인철 | - |
dc.contributor.nonIdAuthor | 이판종 | - |
dc.contributor.nonIdAuthor | 최태부 | - |
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