HEPATOCYTE GROWTH-FACTOR ENHANCES B-CELL ACTIVITY

Hepatocyte growth factor (HGF), is one of the growth factors induced and secreted into the serum of partially hepateceomized or hepatotoxin-treated mice that mediates regeneration of hepatic tissue. Results are presented here demonstrating that in addition to hepatotrophic effects, HGF also possesses immunologic activity. In particular, addition of HGF to B6C3F1 mouse spleen cell cultures enhanced humoral immune responses by augmenting the ability of B-cells to secrete immunoglobulin.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
1993
Language
ENG
Keywords

MOLECULAR-CLONING; HEPATOPOIETIN-A; MESSENGER-RNA; C-MET; EXPRESSION; RECEPTOR; CDNA

Citation

LIFE SCIENCES, v.53, no.5, pp.89 - 93

ISSN
0024-3205
DOI
10.1016/0024-3205(93)90654-L
URI
http://hdl.handle.net/10203/63240
Appears in Collection
BS-Journal Papers(저널논문)
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