Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines

Cited 166 time in webofscience Cited 167 time in scopus
  • Hit : 685
  • Download : 2
DC FieldValueLanguage
dc.contributor.authorCorry, DBko
dc.contributor.authorKiss, Ako
dc.contributor.authorSong, LZko
dc.contributor.authorSong, Lko
dc.contributor.authorXu, Jko
dc.contributor.authorLee, Seung-Hyoko
dc.contributor.authorWerb, Zko
dc.contributor.authorKheradmand, Fko
dc.date.accessioned2008-07-15T05:24:05Z-
dc.date.available2008-07-15T05:24:05Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2004-04-
dc.identifier.citationFASEB JOURNAL, v.18, no.6, pp.995 - 995-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10203/5826-
dc.description.abstractThe mechanisms that initiate allergic lung inflammation are relevant to expression of diseases such as asthma, but the factors underlying resolution of inflammation are equally important. Previously, we demonstrated the importance of matrix metalloproteinase 2 (MMP2) for airway egression of lung eosinophils, a critical anti-inflammatory mechanism without which mice are rendered highly susceptible to lethal asphyxiation. Here we show that leukocyte MMP9 is the dominant airway MMP controlling inflammatory cell egression. The allergic lung phenotype of MMP9(-/-) mice was similar to WT and was not altered by concomitant deletion of the MMP2 gene ( double knockout; dko). However, inflammatory cells accumulated aberrantly in the lungs of allergen-challenged MMP9(-/-) and dko mice and fewer eosinophils and neutrophils were present in bronchoalveolar lavage. These aberrant cellular trafficking patterns were explained by disruption of transepithelial chemokine gradients, in MMP2(-/-) mice affecting only eotaxin (CCL11), but in MMP9(-/-) and dko mice involving eotaxin, MARC (CCL7), and TARC (CCL17). Thus, by establishing multiple transepithelial chemokine gradients, MMP9 is broadly implicated in the resolution of allergic inflammation, an essential protective mechanism that overlaps with a more limited role played by MMP2.-
dc.description.sponsorshipThis study was supported by grants from the National Institutes of Health (HL 72419 and K025 HL 72062 to F.K., HL 69585 to D.C., and AI 53194 to Z.W.), and by funds from the Sandler Family Sustaining Foundation.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherFEDERATION AMER SOC EXP BIOL-
dc.subjectBRONCHIAL EPITHELIAL-CELLS-
dc.subjectMATRIX METALLOPROTEINASES-
dc.subjectAIRWAY HYPERREACTIVITY-
dc.subjectADAPTIVE IMMUNITY-
dc.subjectGELATINASE B-
dc.subjectMURINE MODEL-
dc.subjectIN-VIVO-
dc.subjectASTHMA-
dc.subjectMICE-
dc.subjectEOSINOPHILS-
dc.titleOverlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines-
dc.typeArticle-
dc.identifier.wosid000221108800025-
dc.identifier.scopusid2-s2.0-3543136879-
dc.type.rimsART-
dc.citation.volume18-
dc.citation.issue6-
dc.citation.beginningpage995-
dc.citation.endingpage995-
dc.citation.publicationnameFASEB JOURNAL-
dc.identifier.doi10.1096/fj.03-1412fje-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Seung-Hyo-
dc.contributor.nonIdAuthorCorry, DB-
dc.contributor.nonIdAuthorKiss, A-
dc.contributor.nonIdAuthorSong, LZ-
dc.contributor.nonIdAuthorSong, L-
dc.contributor.nonIdAuthorXu, J-
dc.contributor.nonIdAuthorWerb, Z-
dc.contributor.nonIdAuthorKheradmand, F-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorchemotaxis-
dc.subject.keywordAuthorcytokines-
dc.subject.keywordAuthorgelatinase B-
dc.subject.keywordAuthormatrix metalloproteinase-9-
dc.subject.keywordPlusBRONCHIAL EPITHELIAL-CELLS-
dc.subject.keywordPlusMATRIX METALLOPROTEINASES-
dc.subject.keywordPlusAIRWAY HYPERREACTIVITY-
dc.subject.keywordPlusADAPTIVE IMMUNITY-
dc.subject.keywordPlusGELATINASE B-
dc.subject.keywordPlusMURINE MODEL-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusASTHMA-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusEOSINOPHILS-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 166 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0