Study of phase behavior of nonionic and cationic lipids mixed monolayer at an Air/Water interface = 공기/물 계면에서 중성지질과 양이온지질의 혼합 단분자막 상거동 연구

The study about the mixture of ionic and nonionic lipids impacts understanding of biological membranes and the gene therapeutic application as a gene carrier. In this thesis, we studied the two-dimensional properties of the mixture of cationic and neutral lipids by using the surface balance, surface wave spectroscopy, and ellipsometry. We observed the effect of ionic lipids on the phase behavior of nonionic lipids monolayer at an air-water interface. From the enhanced damping of the capillary wave, we can confirm that the surface pressure of the neutral lipid monolayer increases after the phase transition from the gaseous to expanded liquid state, which is not observable in the surface pressure measurement due to experimental errors. Another interesting result is that the small amount of ionic lipids about 10 mol% strongly prevents the phase transition from the gaseous to expanded liquid state of the nonionic lipid. When we consider the two-body interactions, there exist less attractive interaction between neutral and cationic lipid molecules than two neural lipids.
Advisors
Kim, Mahn-Wonresearcher김만원researcher
Publisher
한국과학기술원
Issue Date
2003
Identifier
179983/325007 / 020013043
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 물리학과, 2003.2, [ viii, 61 p. ]

Keywords

monolayer; 인지질; 표면파; 단분자막; surface wave; lipid

URI
http://hdl.handle.net/10203/48632
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=179983&flag=t
Appears in Collection
PH-Theses_Master(석사논문)
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