Communications to the editor

One of the most widely investigated temperature-sensitive polymers is Pluronic, which is poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (PEO-PPO-PEO) triblock copolymer.1 The aqueous solution of Pluronic showed sol-to-gel (lower temperature region) and gel-to-sol (higher temperature region) transition behaviors with increasing temperature,2 and it is proposed that Pluronic had possibility to be used as injectable drug delivery system.3 The transition behaviors were studied by many researchers with various instruments such as light scattering,4 SANS,5 UV,6 DSC,7 cryo-TEM,8 dielectric measurement,9 and rheology,10. It has been proved that the transition behavior is due to the formation of micelle and micelle packing over specific temperature and concentration.1-10 However, Pluronic was limited in use as injectable drug delivery system because of its nondegradability, toxicity, and dissolution of the gel after administration.11
Publisher
Amer Chemical Soc
Issue Date
2001-09
Language
ENG
Citation

MACROMOLECULES, v.34, pp.8821 - 8824

ISSN
0024-9297
URI
http://hdl.handle.net/10203/3951
Appears in Collection
CBE-Journal Papers(저널논문)
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