Partial reduction of active amides to aldehydes by tri-n-butyltin hydride = 트리부틸틴 히드리드에 의한 활성화아미드에서 알데히드로의 부분적 환원반응

1-Acyl-3-methylimidazole-2-thiones, easily prepared from acid chlorides and 2-mercapto-1-methylimidazole were reduced to the corresponding aldehydes with tri-n-butyltin hydride in refluxing toluene. The aldehydes were obtained in good yields. The present method appeares to be applicable to the synthesis of aldehydes from both aliphatic and aromatic acid derivatives having functional groups such as nitro, double bond and carbonyl group. These partial reductions may occur via a nonradical mechanism. Other active amides and esters such as 3-acylthiazolidine-2-thiones, N-acylimidazoles, S-2-pyridyl thioesters, 2-pyridyl esters did not work well with tri-n-butyltin hydride.
Advisors
Kim, Sung-Gakresearcher김성각researcher
Publisher
한국과학기술원
Issue Date
1989
Identifier
66567/325007 / 000871298
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 1989.2, [ iii, 52 p. ]

URI
http://hdl.handle.net/10203/32539
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=66567&flag=t
Appears in Collection
CH-Theses_Master(석사논문)
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