The in vitro blood compatibility of poly(ethylene oxide)-grafted polyurethane/polystyrene interpenetrating polymer networks

Poly(ethylene oxide) (PEO)-grafted polyurethane (PU)/polystyrene (PS) interpenetrating polymer networks (IPNs) were synthesized. The effects of the mobile pendant PEO chains with their microphase separated structure on blood-compatibility were investigated. The morphology of both the fracture surface as well as the top surface indicate that the size of the dispersed domains of the PS-rich phase decreased as the grafting with the PEO was increased. The swelling ratio also decreased as the grafting with the PEO was increased. However, the dynamic contact angle and the interfacial energy between IPN surface and water decreased, due to the structural reorganization of the pendant PEO chains. PU/PS IPNs have an excellent mechanical property as compared with PU homopolymers. The adsorption of bovine plasma fibrinogen (BPF) onto the PU/PS IPNs and PU homopolymers was effectively suppressed by the PEG-grafting. In the platelet adhesion test; the amount of platelets adsorbed. activated, and/or coagulated upon the PEO-grafted PU/PS IPNs were reduced when compared to the ungrafted PU homopolymers.
Publisher
Vsp Bv
Issue Date
1999-10
Language
ENG
Keywords

HYDROPHOBIC POLYSTYRENE IPNS; PROTEIN-RESISTANT SURFACES; HUMAN-SERUM-ALBUMIN; POLYETHYLENE OXIDE; PLATELET-ADHESION; FORCE MICROSCOPY; HUMAN-FIBRINOGEN; ADSORPTION; ANTITHROMBOGENICITY; MICROSTRUCTURE

Citation

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.11, no.2, pp.197 - 216

ISSN
0920-5063
URI
http://hdl.handle.net/10203/3192
Appears in Collection
CBE-Journal Papers(저널논문)
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