A novel method of microneedle array fabrication using inclined deep x-ray exposure

We report a novel fabrication method for the microneedle array with a 3-dimentional feature and its replication method; Hot-pressing process with bio-compatible material, PLLA (Poly L-LActide). Using inclined deep X-ray exposure technique, we fabricate a band type microneedle array with a single body on the same material basement. Since the single body feature does not make adhesion problem with the microneedle shank and basement during peel-off step of a mold, the PMMA (Poly-Methyl-MethAcrylate) microneedle array mold insert can be used for mold process which is used with the soft material mold, PDMS (Poly-Di- Methyl-Siloxane). The side inclined deep X-ray exposure also makes complex 3-dimentional features by the regions which are not exposed during twice successive exposure steps. In addition, the successive exposure does not need an additional mask alignment after the first side exposure. The fabricated band type microneedle array mold inserts are assembled for large area patch type out-of-plane microneedle array. The bio-compatible microneedle array can be fabricated to the laboratory scale mass production by the single body PMMA mold insert and Hot-pressing process. ? 2006 IOP Publishing Ltd.
Publisher
Institute of Physics
Issue Date
2006-04
Language
ENG
Citation

JOURNAL OF PHYSICS: CONFERENCE SERIES, v.34, no.1, pp.180 - 186

ISSN
1742-6588
URI
http://hdl.handle.net/10203/2752
Appears in Collection
ME-Journal Papers(저널논문)
  • Hit : 417
  • Download : 16
  • Cited 0 times in thomson ci

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0