We report a novel fabrication method for the microneedle array with a 3-dimentional feature and its replication method; Hot-pressing process with bio-compatible material, PLLA (Poly L-LActide). Using inclined deep X-ray exposure technique, we fabricate a band type microneedle array with a single body on the same material basement. Since the single body feature does not make adhesion problem with the microneedle shank and basement during peel-off step of a mold, the PMMA (Poly-Methyl-MethAcrylate) microneedle array mold insert can be used for mold process which is used with the soft material mold, PDMS (Poly-Di- Methyl-Siloxane). The side inclined deep X-ray exposure also makes complex 3-dimentional features by the regions which are not exposed during twice successive exposure steps. In addition, the successive exposure does not need an additional mask alignment after the first side exposure. The fabricated band type microneedle array mold inserts are assembled for large area patch type out-of-plane microneedle array. The bio-compatible microneedle array can be fabricated to the laboratory scale mass production by the single body PMMA mold insert and Hot-pressing process. ？ 2006 IOP Publishing Ltd.