DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Choi, Byong-seok | - |
dc.contributor.advisor | 최병석 | - |
dc.contributor.author | Sung, Sieun | - |
dc.date.accessioned | 2019-08-25T02:51:13Z | - |
dc.date.available | 2019-08-25T02:51:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842450&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/265512 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[ix, 100 p. :] | - |
dc.description.abstract | Retinoic acid-inducible gene I (RIG-I) is a cytosolic receptor of viral RNA and recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5’ phosphates. Critical role of viral RNAs is recognizing viral RNAs and induces type I interferons. A few reports of 5’- PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5’-triphosphate moiety. Here, we report that noncanonical synthetic RNA oligonucleotides containing G-U wobble base pairs that form a bent helix can exert RIG-I-mediated antiviral and anti-tumor effects in a sequence- and site-dependent manner. We also implies that structural dynamics of synthetic RNAs conserving G-U wobble base pairs by using NMR spectroscopy. We present synthetic RNAs that have been systematically modified to enhance their efficacy and outline the basic principles for engineering RIG-I agonists applicable to immunotherapy. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | RIG-I▼atriphosphate▼abent RNA duplex▼aimmunotherapy | - |
dc.subject | RIG-I▼a삼인산▼a이중나선 굽힘▼a면역치료제 | - |
dc.title | RIG-I ligands study as effective antiviral and anti-tumor immunotherapy | - |
dc.title.alternative | 항바이러스 및 항암 면역치료제로써의 효과적인 RIG-I 리간드에 관한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 성시은 | - |
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