DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chang, Sukbok | - |
dc.contributor.advisor | 장석복 | - |
dc.contributor.author | Park, Yoonsu | - |
dc.date.accessioned | 2019-08-25T02:51:00Z | - |
dc.date.available | 2019-08-25T02:51:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842463&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/265500 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[vi, 127 p. :] | - |
dc.description.abstract | Catalytic functionalization of a carbon-hydrogen to carbon-nitrogen bond is one of the most efficient synthetic transformation to prevalent nitrogen-containing molecules. Although a number of innovative methodologies have been devised for the last decade, fundamental understanding of catalytic mechanism is still infancy and further improvement of the reaction still lie ahead. This dissertation describes the reaction mechanism-guided discovery of novel nitrene precursors and their applications in catalytic C–H amidation protocols, which displayed excellent level of efficiency and selectivity. The important results are (i) development of 1,4,2-dioxazol-5-one compounds as efficient amide agents for (pentamethylcyclopentadienyl)rhodium- and iridium catalysis, (ii) integrated experimental and computational mechanism study for an origin of the reactivity, (iii) leveraging the reactivity of a transient intermediate to envision catalytic C–H insertion reactions and their asymmetric variant, and (iv) applying statistical tools to analyze site- and enantioselectivity of C–H functionalization reactions. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Reaction mechanisms▼aSynthetic methodology▼aTransition metal catalysis▼aAsymmetric catalysis▼aC-H Amidation▼aReaction kinetics▼aDensity functional theory▼aMultivariate analysis | - |
dc.subject | 반응 메커니즘▼a합성적 방법론▼a전이 금속 촉매 작용▼a비대칭성 촉매 작용▼a탄소-수소 아미드화▼a반응 속도론▼a밀도 범함수 이론▼a다변량 분석 | - |
dc.title | Mechanism-driven approaches to site- and enantioselective C−H amidation reactions by developing robust nitrene precursors | - |
dc.title.alternative | 나이트렌 전구체의 개발을 통한 위치 및 거울상 선택적 탄소-수소 아미드화의 반응 메커니즘 기반 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 박윤수 | - |
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